Health Condition 1: C539- Malignant neoplasm of cervix uteri, unspecified
Conditions
Sponsors
Institutional Intramural Funds Tata Memorial Centre
Eligibility
Inclusion criteria
Inclusion criteria: 1) Biopsy proven squamous cell cancer of Cervix uteri. 2) Patients with age more than 18 years or less than 80 years. 3) ECOG (0,1,2) 4) Patients amenable for curative intent treatment. 5) Suitable for Brachytherapy boost. 6) Have given their consent for the study. 7) FIGO Stage II,III
Exclusion criteria
Exclusion criteria: 1) Patients with distant metastasis 2) Previous history of abdominal or pelvic radiotherapy / partial or total hysterectomy / neoadjuvant chemotherapy 4) Severe medical condition impairing complete treatment delivery 5) Immunocompromised states and psychological illness 6) Patients planned only either for EBRT, or Brachytherapy 7) Pregnant and lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Study the miRNA expression (miR-106b-5p, miR-186-3p, miR-125b, miR-16-5p, miR-7-5p, miR-29a) and IHC markers p16, MSI and PD-L1 in curative intent treatment naive cervical cancerTimepoint: 1.5 years | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical correlation with the baseline expression of these molecular markers and their potential as predictive and prognostic markersTimepoint: 1.5 years | — |
Countries
India
Contacts
Public ContactDr Abhishek Shinghal
Mahamana Pandit Madan Mohan Malviya Cancer Centre, Varanasi
Outcome results
None listed