Comparing two doses of a muscle relaxant drug

Randomized prospective study to compare two different doses of CIS atracurium using train of four neuromuscular monitoring regarding intubating conditions and hemodynamic parameters - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/06/068856

Enrollment

Registered

2024-06-13

Start date

Unknown

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Endotracheal Intubation: Endotracheal Intubation will be done for patients who will undergo General Anaesthesia during elective surgeries. Control Intervention1: CIS Atracurium 0.15mg/k

Eligibility

Inclusion criteria

Inclusion criteria: - ASA grade I and Grade II Patients - Age 18 - 65 years of age of either sex - Patients undergoing elective surgery under General Anaesthesia

Exclusion criteria

Exclusion criteria: - Patient refusal, - Pregnant or lactating women - Patient with known sensitivity to neuromuscular drug - Anticipated Difficult airway - Patient on medication with antidepressents, anticonvulsants or antihistamine within one -week before the study - History of alcoholism, neurologic, psychiatric or respiratory diseases. - Patients of type 2 diabetes mellitus and hypertension and obese patients or any severe systemic disease. - Cardio-vascular diseases including ischemic heart disease.

Design outcomes

Primary

Measure	Time frame
To evaluate intubating conditions jaw relaxation, vocal cord mobility, movement of limbs, TOF ratio, mean time from neuro-muscular blocking to tracheal intubation, any adverse events, clinical Duration of loading dose of non-depolarizing neuromuscular blocking agent)using train of four neuromuscular monitoring with two different doses of cisatracurium.Timepoint: - Monitoring will be done after giving loading dose of non depolarising neuromuscular blocking agent every 30 seconds till 4 minutes, followed by every 5 minutes till 30 minutes	—

Measure

Time frame

To evaluate intubating conditions jaw relaxation, vocal cord mobility, movement of limbs, TOF ratio, mean time from neuro-muscular blocking to tracheal intubation, any adverse events, clinical Duration of loading dose of non-depolarizing neuromuscular blocking agent)using train of four neuromuscular monitoring with two different doses of cisatracurium.Timepoint: - Monitoring will be done after giving loading dose of non depolarising neuromuscular blocking agent every 30 seconds till 4 minutes, followed by every 5 minutes till 30 minutes

—

Secondary

Measure	Time frame
To compare systemic effect of two different doses of cisatracurium on hemodynamic parameters (viz.heart rate ,systolic and diastolic blood pressure,oxygen saturation)Timepoint: - Monitoring will be done after giving loading dose of non depolarising neuromuscular blocking agent every 30 seconds till 4 minutes, followed by every 5 minutes till 30 minutes	—

Countries

India

Contacts

Public ContactDr Peeyush Vidyarthi

LLRM Medical College

nickysangeeta78@gmail.com9568766156

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026