The study is looking at whether irrigation in a joint procedure, or taking a medication by mouth, or doing both together is the best way to treat jaw joint problems.

A randomized controlled trial comparing the effectiveness of arthrocentesis alone, oral duloxetine alone, and a combination of both in the treatment of temporomandibular joint disorders. - Tmj

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/06/068839

Enrollment

Registered

2024-06-13

Start date

Unknown

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K088- Other specified disorders of teethand supporting structures

Interventions

Intervention1: Oral duloxetine: All patients requiring minor oral surgical procedure having tmj pain with vas score 5 or more. Intervention2: Arthrocentesis with oral duloxetine: All patients requirin

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patient willing to participate in study. 2.Patients in the age group of 18 -60 years. 3.Patients diagnosed with TMJ arthralgia and intra articular TMJ disorders as given by DC TMD criteria. 4.Patients with VAS score 5 or more pre-operatively

Exclusion criteria

Exclusion criteria: 1.Patients having systemic diseases in which duloxetine is contraindicated. 2.Patients with coagulation disorders. 3.Allergic reaction to local anesthetic agents and duloxetine. 4.TMJ pain following traumatic injury.

Design outcomes

Primary

Measure	Time frame
To evaluate the efficacy of arthrocentesis, oral duloxetine alone and combination of arthrocentesis with oral duloxetine in reducing pain in temporomandibular joint disorders.Timepoint: VAS score at day1, day7, 1st month, 3rd month	—

Secondary

Measure	Time frame
To evaluate the efficacy of arthrocentesis, oral duloxetine alone and combination of arthrocentesis with oral duloxetine in improving the maximum mouth opening in temporomandibular joint disordersTimepoint: Maximum mouth opening at day1, day7, 1st month,3rd month	—

Countries

India

Contacts

Public ContactDr Damini Hiralal Nikhar

Terna dental college and hospital

sanjoshi99@gmail.com9869057337

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026