Health Condition 1: C800- Disseminated malignant neoplasm, unspecified Health Condition 2: C349- Malignant neoplasm of unspecifiedpart of bronchus or lung
Conditions
Interventions
Intervention1: Y-90 microsphere radioembolisation: transarterial radioembolisation with the above mentioned agent to be done via the predominant tumor feeding pulmonary or bronchial artery
Control Int
Sponsors
Bela Jain senior resident
Eligibility
Inclusion criteria
Inclusion criteria: measureable metastatic lung lesions (Biopsy proven or positive on FDG PET CT), ECOG less than or equal to 2, Karnofsky score more than 60, Hemoglobin more than 9 g/dl, WBC more than 1500/microlitre, platelets more than 50000/microlitre, PT less than 1.3 and INR less than 1.5, FEV1more than 60%, serum creatinine less than 1.3
Exclusion criteria
Exclusion criteria: previous history of interstitial lung disease, COPD, active lung infection, pulmonary hypertension, pulmonary AV malformation, Symptomatic heart failure, LBBB, Predictive dose to lung parenchyma exceeding 30 Grey in dose planning, allergy to contrast/plastic, renal failure, coagulative disorder, survival expectancy of less than 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| size of lung lesion to be measured on FDG PET CT to see for any reduction in size/resolutionTimepoint: 6 weeks, 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| To establish the dose response relationship of transarterial radioembolization in metastatic lung lesions using volumetric methods. Response to be assessed using FDG PET CTTimepoint: 6 weeks, 3 months | — |
Countries
India
Contacts
Public ContactDr Bela Jain
AIIMS, New Delhi
Outcome results
None listed