To assess the outcome of using calcium hydroxide with and without Zinc oxide nanoparticle root canal medicament as an intervention in diabetic and healthy participants with infected root canals.

Antibacterial efficacy of combined zinc nanoparticles-calcium hydroxide root canal medication in healthy and diabetic patients with apical periodontitis - A case-control study - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/06/068819

Enrollment

Registered

2024-06-12

Start date

Unknown

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K045- Chronic apical periodontitis Health Condition 2: E119- Type 2 diabetes mellitus without complications

Interventions

Intervention1: zinc oxide nanoparticles with calcium hydroxide: Two groups of healthy and diabetic patients receive intracanal medicament of zinc oxide nanoparticles combined with calcium hydroxide Co

Eligibility

Inclusion criteria

Inclusion criteria: Patients with controlled type 2 diabetes (HbA1c level is 6.5% or below)having non-vital teeth with apical periodontitis Radiographic evidence of apical periodontitis (PAI score: 2-5)

Exclusion criteria

Exclusion criteria: Systemic factors such as pregnancy, and other co-existing immunocompromised conditions that can impair healing. Previously endodontically treated teeth Teeth with gross carious lesions (unrestorable), root fractures, open apex, intraoral and extraoral swelling, and extraoral sinus opening. Cases showing periodontal pockets deeper than 4 mm. Patients on antibiotic medications within 3 previous months.

Design outcomes

Primary

Measure	Time frame
Analyze and quantify the antimicrobial effect of combined ZnO NP-Ca(OH)2 against common endodontic bacteria found in diabetic and healthy patients with pulp necrosis and/or apical periodontitis, by estimating the CFU of canal biofilm.Timepoint: 6 months	—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactDr Paras Mull J

JSS Dental College And Hospital

dr.parasmullj@jssuni.edu.in9845854977

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026