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A study to evaluate the practice of Fluid Therapy in very sick patients on mechanical ventilator

Practice of Fluid Therapy in Critically Ill Invasively Ventilated Patients (PRoFLUID)â?? an international multicenter observational cohort study - PRoFLUID

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/06/068806
Enrollment
2500
Registered
2024-06-12
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: C00-D49- Neoplasms

Interventions

Intervention1: Nil: NA Control Intervention1: Nil: NA

Sponsors

Amsterdam University Medical Centers, location â??AMCâ??
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. admitted to a participating ICU 2. receiving invasive ventilation within 3 days of ICU admission and 3. duration of ventilation more than 24 hours

Exclusion criteria

Exclusion criteria: 1. Age less than 18 years 2. patients transferred under invasive ventilation from another ICU

Design outcomes

Primary

MeasureTime frame
The primary outcome is a composite of various aspects of fluid therapy, including total volumes of types of fluids administered in the first three days after start of invasive ventilation and total volume of fluids infused in the first seven days after start of invasive ventilation.Timepoint: At day 3 and day 7 of start of invasive ventilation in ICU

Secondary

MeasureTime frame
Secondary outcomes include timing of start, type, and duration of continuous administration of vasopressors; timing of start, infusion time and types of administered diuretics; daily urine output and cumulative fluid balances; and typical ICU outcomes, like duration of ventilation, lengths of stay in ICU and hospital, and mortality in the ICU and hospital.Timepoint: At day 28, 60 and 90

Countries

India, Netherlands

Contacts

Public ContactDr Sheila Nainan Myatra

Tata Memorial Hospital

sheila150@hotmail.com9820156070

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026