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Comparison of different Irrigants and Activation Systems for disinfection of root canals

Comparative Evaluation Of Antimicrobial Efficacy Of Different Irrigants and Activation Systems in Primary Endodontic Infections- An in vivo study. - NIL

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/06/068770
Enrollment
90
Registered
2024-06-12
Start date
Unknown
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K041- Necrosis of pulp

Interventions

Intervention1: Sonic Activation: Sonic activation has been divided into 2 groups on the basis of irrigants that is 2% CHX and 2.5% NaOCL After bio-mechanical preparation canals irrigated with the resp

Sponsors

Sudha Rustagi College of Dental Sciences And Research
Lead Sponsor
SONIC ACTIVATOR EQS Metabiomed
Collaborator
Ultrasonic activator EndoUltra
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Patients with non-contributory medical history, permanent teeth diagnosed as nonvital clinically using pulp vitality tests, teeth with adequate coronal structure to ascertain proper isolation, sterilization, temporization, and restoration will be included.

Exclusion criteria

Exclusion criteria: Patients with systemic diseases, immuno-compromised conditions, pregnant patients, patients on any antibiotic therapy within three months from the beginning of the treatment, patients with acute periapical abscess, periapical lesion, retreatment cases, teeth with calcified canals, immature apex, presence of intraoral or extra-oral sinus, internal and external root resorption, fractured roots and periodontal pockets >5 mm will be excluded.

Design outcomes

Primary

MeasureTime frame
To evaluate the antimicrobial efficacy of 2.5% NaOCl and 2% CHX with conventional needle irrigation, sonic, and ultrasonic activation in primary endodontic infections and To compare the antimicrobial efficacy of 2.5% NaOCl and 2% CHX with conventional needle irrigation, sonic, and ultrasonic activation in primary endodontic infections by estimating reduction of bacterial countsTimepoint: 2 months

Secondary

MeasureTime frame
Comparison in reduction of bacterial counts at two stages - before biomechanical preparation (S1) and after biomechanical preparation (S2) of each sample.Timepoint: 45 minutes

Countries

India

Contacts

Public ContactDr Tanya Dua

Sudha Rustagi College of Dental Sciences And Research

drashimasood@gmail.com9971444100

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Sep 19, 2026