Treatment of Chronic Periodontitis with Open Flap surgery along with Platelet- rich Fibrin (PRF) to see its effect on agents causing inflammation (MIP-1a).

Evaluation and Co-relation of Macrophage Inflammation Protein (MIP-1a) in Gingival Crevicular Fluid (GCF) of patients suffering from Chronic Periodontitis, treated with Open Flap debridement with and without Platelet rich Fibrin- A Split-Mouth Randomized Controlled Clinical Trial. - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/06/068754

Enrollment

Registered

2024-06-12

Start date

Unknown

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Open flap surgery with Platelet- rich fibrin: Biomaterial is prepared by following the protocol developed by Choukroun et al in 2001. 10ml of blood is centrifuged at 1500 rpm for 12 min

Eligibility

Inclusion criteria

Inclusion criteria: 1. Chronic periodontitis patients with Probing depth- = to 4mm and = 7mm (AAP Classification 2017). 2. Presence of at least = to 20 natural teeth in both upper and lower arches.

Exclusion criteria

Exclusion criteria: 1. Subjects using smoked and smokeless tobacco. 2. Pregnant and lactating females. 3. Subjects with history of uncontrolled systemic diseases affecting the periodontium. 4. Subjects allergic to medications prescribed during treatment. 5. Subjects who have received surgical or non- surgical periodontal therapy 6 months prior. 6. Those undergoing antibiotic and anti- inflammatory therapy or have had in last 6 months. 7. Post-menopausal women.

Design outcomes

Primary

Measure	Time frame
1.Plaque Index (PI)- Silness and Loe(1964) 2.Gingival Index (GI)- Loe and Silness (1963) 3.Bleeding Index (BI)- Ainamo and Bay (1975) 4.Relative Pocket Probing Depth (PPD) 5.Wound healing Index (WHI)- (Landry et. al. 1988) 6.Relative Attachment Level (RAL) 7. ELISA for biomarkerTimepoint: Measured at 0, 3 and 6 months	—

Secondary

Measure	Time frame
Phenotype for gingivaTimepoint: Measured at 0, 3 and 6 months	—

Countries

India

Contacts

Public ContactDr Arunima Bansal

ITS Dental College Hospital and Research Centre, Greater Noida

prin.dntl.gn@its.edu.in9910222799

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026