The effect of intrathecal morphine on postoperative Natural Killer Cell activity in patients undergoing surgery for pancreatobiliary cancers.

The effect of intrathecal morphine on postoperative Natural Killer Cell activity in patients undergoing abdominal surgery for pancreatobiliary malignancy:A randomized control trail. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/06/068748

Enrollment

Registered

2024-06-12

Start date

Unknown

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intrathecal morphine: 200µg morphine will be administered to the intrathecal space before induction of General Anaesthesia in the operating room. Control Intervention1: Sham procedure:

Eligibility

Inclusion criteria

Inclusion criteria: All patients aged 18 to 65years (American society of anaesthesiologist grading I, II, III) to be taken upfront for major abdominal surgeries for pancreatobiliary malignancy.

Exclusion criteria

Exclusion criteria: 1.Patients with ASA grade greater than 3. 2.Patients having chronic pain or any opioid treatment. 3.Patients expected to be requiring postoperative ventilation support. 4.Patients with pre-existing immunodeficiency. 5.Any ongoing infections in patient. 6.Any other chronic inflammatory conditions such as Rheumatoid Arthritis etc. 7.Patients on chemotherapy or radiotherapy. 8.History of blood transfusion in last 15 days

Design outcomes

Primary

Measure	Time frame
To measure effect of, addition of intrathecal morphine to post operative pain management regime, on postoperative Natural Killer Cell quantity in patients posted for pancreato-biliary malignancy surgery.Timepoint: 24 hours	—

Secondary

Measure	Time frame
To assess Pain using NRS score following surgery at 6th, 12th, 24th, 36th, 48th hour post operatively.Timepoint: 48hours;To assess Patient satisfaction score using likert scale.Timepoint: 24hours;To assess Quality of recovery using QOR 15 Score postoperatively.Timepoint: 24hours;To assess time for first rescue analgesia in both the study groups.Timepoint: 24hours;To calculate total opioid consumption post operatively in both study groups.Timepoint: 24hours;To measure the effect on Serum CRP levels postoperatively.Timepoint: 24hours;To report any side effects like postoperative nausea and vomiting etc.Timepoint: 24hours	—

Measure

Time frame

To assess Pain using NRS score following surgery at 6th, 12th, 24th, 36th, 48th hour post operatively.Timepoint: 48hours;To assess Patient satisfaction score using likert scale.Timepoint: 24hours;To assess Quality of recovery using QOR 15 Score postoperatively.Timepoint: 24hours;To assess time for first rescue analgesia in both the study groups.Timepoint: 24hours;To calculate total opioid consumption post operatively in both study groups.Timepoint: 24hours;To measure the effect on Serum CRP levels postoperatively.Timepoint: 24hours;To report any side effects like postoperative nausea and vomiting etc.Timepoint: 24hours

—

Countries

India

Contacts

Public ContactDr Priyanka Sethi

All India Institute of Medical Sciences, Jodhpur

dr.priyanka_sethi@yahoo.co.in9352206300

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026