Effectiveness of Antirabies vaccine using two dose ,two site subcutaneous route in children who are not exposed to rabies

Immunogenicity of two dose, two site subcutaneous anti-rabies vaccine as a pre-exposure prophylaxis in children. - nil

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/06/068665

Enrollment

Registered

2024-06-11

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: AntiRabies Vaccine: Antirabies Vaccine will be administered as Two doses 0.1 ml each on Day 0 and Day 7 via Subcutaneous route on two sites over each Deltoid as Preexposure prophylaxis

Eligibility

Inclusion criteria

Inclusion criteria: Children and Adolescents between 2 to 18 years presenting to Lok Nayak Hospital OPD for minor ailments.

Exclusion criteria

Exclusion criteria: 1. Children with prior rabies immunization or history of animal bite. 2. Children with animal bite during the study period. 3. Children with known chronic illnesses. 4. Children receiving any vaccine less than a month ago. 5. Children on immunosuppressive drugs 6. Children with known Allergy to any of the components of the vaccine.

Design outcomes

Primary

Measure	Time frame
1.Proportion of children with IgG anti rabies virus glycoprotein titres equal to or more than 0.5 EU/ml after 2 doses of subcutaneous Pre-Exposure Rabies Prophylaxis on day 28 in children and adolescents between 2 to 18 years of age.Timepoint: On Day 28+7 where Day 0 is the day of first dose of Antirabies vaccine	—

Secondary

Measure	Time frame
1. Proportion of children with IgG anti rabies virus glycoprotein titres equal to or more than 0.5 EU/ml after 2 doses of subcutaneous Pre-Exposure Rabies Prophylaxis on day 90 in children & adolescents between 2 to 18 years of age. 2. Proportion of subjects having various kinds of adverse effects after two dose two site subcutaneous preexposure prophylaxis regimen using rabies cell culture vaccine. Timepoint: On Day 90 plus 7 days	—

Measure

Time frame

1. Proportion of children with IgG anti rabies virus glycoprotein titres equal to or more than 0.5 EU/ml after 2 doses of subcutaneous Pre-Exposure Rabies Prophylaxis on day 90 in children & adolescents between 2 to 18 years of age. 2. Proportion of subjects having various kinds of adverse effects after two dose two site subcutaneous preexposure prophylaxis regimen using rabies cell culture vaccine. Timepoint: On Day 90 plus 7 days

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Countries

India

Contacts

Public ContactDr Anurag Agarwal

Maulana Azad Medical College and Lok Nayak Hospital

doctoranuragagarwal@gmail.com9810409625

Outcome results