Clinical evaluation of zinc oxide nanoparticles - containing cavity cleaning agent used in molar milk teeth of children.

Clinical evaluation of the effectiveness of Zinc Oxide nanoparticles-containing cavity disinfectant on the retention of restorations in carious primary molars - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/06/068620

Enrollment

Registered

2024-06-10

Start date

Unknown

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K025- Dental caries on pit and fissure surface Health Condition 2: A488- Other specified bacterial diseases

Interventions

Intervention1: Zinc oxide Nanoparticles: Cavity disinfectant topical application of the solution onto the floor of the cavity for 60 seconds and will be washed and dried. Control Intervention1: NOT AP

Eligibility

Inclusion criteria

Inclusion criteria: Children included- 1.within age of 6-9 years with presence of caries in any primary 1st and 2nd molar 2. moderately deep cavities (ICDAS II caries score 4,5,6) limited to single-surface occlusal lesions 3.systemically healthy and cooperative children (Frankl scale 3 and 4) Radiographic criteria: 1.Children with caries involving enamel, dentin and with at least remaining dentin thickness of at least 0.5mm

Exclusion criteria

Exclusion criteria: Children with- 1.intellectual disability 2.systemic illness and on long term medication 3.presence of root stumps in oral cavity 4.presence of open carious lesions in oral cavity 5.with any known allergy 6.buccal/lingual extension

Design outcomes

Primary

Measure	Time frame
To evaluate and compare the effect of zinc oxide nanoparticles containing cavity disinfectant with that of commercially available chlorhexidine gel on retention of the restorations using FDI clinical scoring criteria Timepoint: assessed at baseline, 3 months, and 6 months	—

Secondary

Measure	Time frame
1.To evaluate & compare the antimicrobial activity of zinc oxide nanoparticles with that of commercially available chlorhexidine gel as a cavity disinfectant in the prepared cavity by using microbial plating. 2.To evaluate & compare the ultrastructure of dentin tubules after disinfection with a zinc oxide-incorporated disinfectant & chlorhexidine on sectioned teeth through scanning electron microscopy (in vitro). Timepoint: at baseline, 3 months, 6 months	—

Measure

Time frame

1.To evaluate & compare the antimicrobial activity of zinc oxide nanoparticles with that of commercially available chlorhexidine gel as a cavity disinfectant in the prepared cavity by using microbial plating. 2.To evaluate & compare the ultrastructure of dentin tubules after disinfection with a zinc oxide-incorporated disinfectant & chlorhexidine on sectioned teeth through scanning electron microscopy (in vitro). Timepoint: at baseline, 3 months, 6 months

—

Countries

India

Contacts

Public ContactDr. Abhinaya Ananthakumar

JSS Dental College and Hospital

seema.pedo@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Sep 19, 2026