Comparing the efficacy of medications that increases blood pressure that is Noradrenaline alone versus Noradrenaline plus Terlipressin in two groups of patients in ICU who admitted with profound low blood pressure following infection.

COMPARATIVE STUDY OF NORADRENALINE ALONE VERSUS NORADRENALINE AND TERLIPRESSIN FOR MANAGEMENT OF SEPTIC SHOCK IN ICU: A PROSPECTIVE RANDOMIZED CONTROLLED STUDY. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/06/068535

Enrollment

Registered

2024-06-06

Start date

Unknown

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: B948- Sequelae of other specified infectious and parasitic diseases

Interventions

Intervention1: Noradrenaline plus Terlipressin: Participants will be recruited and randomized using computer created random number technique using the allocation ratio 1:1. Group 1 patients will recei

Eligibility

Inclusion criteria

Inclusion criteria: Patient with septic shock presenting with mean arterial pressure less than 65 mmHg despite appropriate volume resuscitation.

Exclusion criteria

Exclusion criteria: Patient age less than 18 years, presence of severe comorbid conditions, requirement of any other vasopressor, need of more than 3 mcg/kg/minute of noradrenaline infusion to achieve the target mean arterial pressure.

Design outcomes

Primary

Measure	Time frame
Dose of noradrenaline require to achieve target mean arterial pressure of 65-70 mmHg after 12 hours of starting infusion.Timepoint: Dose of noradrenaline require to achieve target mean arterial pressure of 65-70 mmHg after 12 hours of starting infusion.	—

Secondary

Measure	Time frame
Length of ICU stay Duration of vasopressor requirement Changes in the lactate levels in 12 hours post-initiation of vasopressor infusion. Urine output in ml/hour at 12 hours post-initiation of the vasopressor infusion. Changes in the qSOFA score at 12 hours post initiation of vasopressor infusion. Incidence of serious adverse events like digital ischaemia, cardiac arrythmias, incidence of diarrhoea and upper GI bleed.Timepoint: 12 hours	—

Measure

Time frame

Length of ICU stay Duration of vasopressor requirement Changes in the lactate levels in 12 hours post-initiation of vasopressor infusion. Urine output in ml/hour at 12 hours post-initiation of the vasopressor infusion. Changes in the qSOFA score at 12 hours post initiation of vasopressor infusion. Incidence of serious adverse events like digital ischaemia, cardiac arrythmias, incidence of diarrhoea and upper GI bleed.Timepoint: 12 hours

—

Countries

India

Contacts

Public ContactDR ALTAFUDDIN AHMED

TEZPUR MEDICAL COLLEGE AND HOSPITAL

draltafahmeddbr@Yahoo.in9435032380

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026