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An observational study in critically ill chronic liver disease patients to find out the imbalance between right ventricular workload and functional capacity.

Right ventricle-pulmonary artery uncoupling in critically ill decompensated chronic liver disease patients: an exploratory observational study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/06/068480
Enrollment
250
Registered
2024-06-06
Start date
Unknown
Completion date
Unknown
Last updated
2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K703- Alcoholic cirrhosis of liver Health Condition 2: K754- Autoimmune hepatitis Health Condition 3: K721- Chronic hepatic failure Health Condition 4: K739- Chronic hepatitis, unspecified Health Condition 5: K729- Hepatic failure, unspecified Health Condition 6: K740- Hepatic fibrosis

Interventions

Intervention1: Echocardiography: Echocardiography will be performed with in 24 hours of ICU admission. Tricuspid annular plane systolic excursion (TAPSE) and tricuspid regurgitant jet velocity will be

Sponsors

Institute of Liver and Biliary Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients with chronic liver disease with decompensation requiring ICU care. Disease etiology: chronic liver disease or Acute on chronic liver disease of various etiology like alcoholic liver disease, viral hepatitis, NASH

Exclusion criteria

Exclusion criteria: Pediatric patients acute coronary syndrome within 1week Rhythm characteristics of atrial fibrillation Prosthetic valves or valvular diseases such as severe mitral, aortic or tricuspid stenosis or regurgitation An inadequate echocardiographic images for measurement Patients without tricuspid regurgitation as TRV cannot be calculated in them.

Design outcomes

Primary

MeasureTime frame
To determine incidence of Right ventricle- Pulmonary artery uncoupling (by means of calculating TAPSE/PASP ratio) in patients with decompensated chronic liver disease requiring ICU care.Timepoint: With in 48 hours of ICU admission—

Secondary

MeasureTime frame
Need for ventilatory support, inotrope requirement, MortalityTimepoint: 1st, 3rd, 7th, 14th, 21st, 28th day in ICU—

Countries

India

Contacts

Public ContactDr Aniruddha Banerjee

Institute of Liver & Biliary Sciences

banerjeeaniruddha194@gmail.com08583807964

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026