Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Plasmalyte: It is given intravenously as maintenance and resuscitative fluid therapy in the plasmalyte group. This is given from the onset of surgery till the surgery is completed. Volu
Sponsors
Jipmer intramural grant
Eligibility
Inclusion criteria
Inclusion criteria: 1) American Society of Anesthesiologists (ASA) physical status I, II, III and IV 2) Patient undergoing emergency gastrointestinal perforation surgery
Exclusion criteria
Exclusion criteria: 1) Patient already receiving mechanical ventilation 2) Patient already receiving inotrope 3) Acute or chronic preexisting kidney disease 4) Uncontrolled diabetes mellitus/patients requiring insulin therapy 5) History of known anaphylactic reaction 6) Hyperkalemia 7) patients with hepatic dysfunction (total bilirubin above 2mg/dl, sgot and sgpt values more than 2 times normal values)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine and compare the effect of plasmalyte and 0.9% saline on intraoperative vasopressors and inotropes requirements undergoing emergency gastrointestinal perforation surgery.Timepoint: At the end of study. (2yrs approx) | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the effect of predefined composite of renal, cardiovascular and respiratory system complications Timepoint: At the end of study. (2yrs approx;To compare the effect on acute kidney injury marker (kidney injury molecule-1) Timepoint: At the end of study. (2yrs approx);To compare the effect on in-hospital mortality, intensive care unit stay and hospital stayTimepoint: At the end of study. (2yrs approx);To compare the effect on postoperative acid-base status and lactateTimepoint: At the end of study. (2yrs approx) | — |
Countries
India
Contacts
Public ContactDr Suman Lata Gupta
JIPMER
Outcome results
None listed