A Comparison of the Property Against the Micro-organisms in the Root Canal, between Octenidine Dihydrochloride Chlorhexidine and Sodium Hypochlorite as Irrigating solutions: A Randomized Controlled Trial

A Comparative Evaluation of Antimicrobial Efficacy of Octenidine Dihydrochloride with Chlorhexidine and Sodium Hypochlorite as Root Canal Irrigants: A Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/06/068447

Enrollment

Registered

2024-06-06

Start date

Unknown

Completion date

Unknown

Last updated

2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: 1. Octenidine Dihydrochloride 2. Sodium Hypochlorite 3. Chlorhexidine Digluconate: 1.0.1% Octenidine Dihydrochloride is an antimicrobial agent, used as a irrigating solution during non

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients without any systemic disease 2. Tooth with fully formed root 3. Tooth diagnosed with systemic irreversible pulpitis 4. Tooth which does not show tenderness on percussion 5. Tooth with no periapical lesion

Exclusion criteria

Exclusion criteria: 1. Patient with systemic disease and co-morbidities 2. Patient with history of medication(antibiotics) 15 days prior to the procedure 3. Tooth with history of previous endodontic treatment 4. Multirooted tooth 5.Non vital tooth 6. Tooth with root caries 7. Tooth with open apex 8. Tooth showing root resorption 9. Tooth with periapical lesion

Design outcomes

Primary

Measure	Time frame
Antimicrobial efficacy of Octenidine Dihydrochloride (0.1%) compared to Sodium hypochlorite (2.5%) and Chlorhexidine Digluconate (2%) as a root canal irrigantTimepoint: Antimicrobial efficacy of Octenidine Dihydrochloride (0.1%) compared to Sodium hypochlorite (2.5%) and Chlorhexidine Digluconate (2%) as a root canal irrigant at baseline, immediately before the chemomechanical preparation and 1 hour after the chemomechanical preparation	—

Measure

Time frame

Antimicrobial efficacy of Octenidine Dihydrochloride (0.1%) compared to Sodium hypochlorite (2.5%) and Chlorhexidine Digluconate (2%) as a root canal irrigantTimepoint: Antimicrobial efficacy of Octenidine Dihydrochloride (0.1%) compared to Sodium hypochlorite (2.5%) and Chlorhexidine Digluconate (2%) as a root canal irrigant at baseline, immediately before the chemomechanical preparation and 1 hour after the chemomechanical preparation

—

Secondary

Measure	Time frame
Antimicrobial efficacy of 2.5% Sodium hypochlorite & 2% Chlorhexidine DigluconateTimepoint: Antimicrobial efficacy of 2.5% Sodium hypochlorite & 2% Chlorhexidine Digluconate at baseline immediately before the chemomechanical preparation & 1 hour after the chemomechanical preparation	—

Countries

India

Contacts

Public ContactSahil Ali

Guru Nanak Institute of Dental Sciences and Research

priti.desai@gnidsr.ac.in9831071632

Outcome results