To evaluate and compare antimicrobial effectiveness of calcium hydroxide, herb Mimusops elengi and Tribulus terrestris as an intracanal medicament on Enterococcus fecalis

A Randomized Clinical Trial to evaluate and compare antimicrobial efficacy of calcium hydroxide herbal Mimusops elengi and Tribulus terrestris as an intracanal medicament on Enterococcus faecalis in permanent teeth - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/06/068437

Enrollment

Registered

2024-06-06

Start date

Unknown

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K045- Chronic apical periodontitis

Interventions

Intervention1: M.elengi herbal intracanal medicament: Raw powder of M.elengi dose 0.22g frequency baseline 15th day 30th day Route of administration intracanal Duration 30 days Control Interven

Eligibility

Inclusion criteria

Inclusion criteria: 1.Permanent teeth with periapical lesion requiring endodontic treatment. 2.Distinct periapical changes visible on intraoral periapical radiograph of permanent teeth.

Exclusion criteria

Exclusion criteria: 1.Teeth with evident clinical signs of extra oral swelling, space infections. 2.Patient on long-term antibiotic therapy, steroid therapy. 3.Patients with any systemic diseases. 4.Grossly decayed tooth indicated for extraction. 5.Parents who deny providing the consent and participation for the study.

Design outcomes

Primary

Measure	Time frame
To evaluate the antimicrobial efficiency of Mimusops elengi, Tribulus terrestris as an intracanal medicament on E.faecalis colony forming units over 30 days time period when compared with calcium hydroxide on permanent teeth by assessing history of pain tenderness on percussion absence of abscess or sinus discharge Timepoint: •1st day –baseline sample collection for microbiological analysis of E.faecalis. •15 day follow up with sample collection for microbiological analysis of E.faecalis. •30 day follow up with sample collection for microbiological analysis of E.faecalis. Time of assessment are first day 15th day and 30th day	—

Measure

Time frame

To evaluate the antimicrobial efficiency of Mimusops elengi, Tribulus terrestris as an intracanal medicament on E.faecalis colony forming units over 30 days time period when compared with calcium hydroxide on permanent teeth by assessing history of pain tenderness on percussion absence of abscess or sinus discharge Timepoint: •1st day –baseline sample collection for microbiological analysis of E.faecalis. •15 day follow up with sample collection for microbiological analysis of E.faecalis. •30 day follow up with sample collection for microbiological analysis of E.faecalis. Time of assessment are first day 15th day and 30th day

—

Secondary

Measure	Time frame
To evaluate the success rate of endodontic therapy over a period of 30 days based on the parameters like absence of pain tenderness to vertical percussion discharge or swelling suggestive of periapical healingTimepoint: 15 days & 30 days post placement of intracanal medicament	—

Countries

India

Contacts

Public ContactDr Shruthi B Patil

SDM College of Dental Sciences and Hospiatl

shruthirajpatil@gmail.com7760372185

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026