comparing intravenous clonidine with lignocaine nebulisation for decreasing heart rate, blood pressure due to laryngoscopy and intubation in patients going for skull surgery under general anaesthesia

Comparison of intravenous Clonidine with nebulised lignocaine for attenuation of hemodynamic response to laryngoscopy and endotracheal intubation in patients posted for craniotomy under general anaesthesia - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/06/068428

Enrollment

Registered

2024-06-06

Start date

Unknown

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Clonidine and Lignocaine: Preoperatively just before induction, group 1 will be nebulised with 4% lignocaine for 10 min and will be given 100 m of normal saline intravenously and group

Eligibility

Inclusion criteria

Inclusion criteria: BMI 18.5-29.9 ASA I and II posted for elective craniotomy procedure under general anaesthesia

Exclusion criteria

Exclusion criteria: Anticipated difficult airway. Patients requiring more than 1 intubation attempt and taking more than 30 seconds for laryngoscopy and intubation. Cardiac disease and hypertensive patients. Pregnant patients. Patients with allergy to study drugs.

Design outcomes

Primary

Measure	Time frame
Measuring the heart rate, blood pressure and mean arterial pressure response to laryngoscopy and endotracheal intubationTimepoint: Preintubation ,at laryngoscopy and endotracheal intubation,at 1 min 2 min 3 min 5 min and at 10 min post intubation.	—

Secondary

Measure	Time frame
Measuring the neuroendocrine response to laryngoscopy and endotracheal intubationTimepoint: Before intubation and post intubation	—

Countries

India

Contacts

Public ContactDr Tina Khurana

ABVIMS and Dr.Ram manohar lohia hospital

tina.khurana1@gmail.com9810617583

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026