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Comparison of two anaesthetic drugs(ketomidate and ketofol)for initiation of anaesthesia among patients with aneurysmal bleed undergoing surgery.

Ketomidate versus Ketofol for Induction of Anesthesia in Patients with Aneurysmal Subarachnoid Hemorrhage Undergoing Clipping Surgery: A Prospective Randomized Double-blind Trial. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/06/068379
Enrollment
92
Registered
2024-06-05
Start date
Unknown
Completion date
Unknown
Last updated
2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Ketomidate: Ketomidate(Ketamine and Etomidate in 1:5 ratio) will be used once intravenously for induction of anaesthesia in patients with aneurysmal sub-arachnoid hemorrhage. Control In

Sponsors

Post Graduate Institute of Medical Education and Research PGIMER Chandigarh
Lead Sponsor
Post Graduate Institute of Medical Education and Research PGIMER Chandigarh
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: ASA IE and IIE, Patients with ruptured cerebral aneurysms with Hunt and Hess (H and H) Grade I– II, World Federation of Neurosurgeons (WFNS) Grade I–II scheduled for aneurysmal clipping surgery will be included in the study.

Exclusion criteria

Exclusion criteria: Patients’ refusal to participate in the study, Patients with Poor- grade aneurysm (H and H grade IV–V,WFNS grade IV–V), Patients with Giant aneurysm, Patient with an anticipated difficult airway, Patients with psychiatric illness, Patients with uncontrolled systemic diseases (CAD, HTN, DM, Asthma).

Design outcomes

Primary

MeasureTime frame
To compare the change in ONSD from baseline after securing the airway between both groups.Timepoint: At 5 minutes after securing the airway.—

Secondary

MeasureTime frame
ONSD will be measured before induction (T0), immediately after establishing the bag & mask ventilation (T1), immediately after intubation (T2), 5 minutes after intubation (T3), & 10 minutes after intubation (T4). Intraoperative brain relaxation score. Comparison of the hemodynamic parameters. Serum cortisol level (pre-operative, & post-operatively at 24 hours). Modified Rankin score (mRS) score at discharge. GOSE at 3 months after discharge.Timepoint: Before induction (T0), immediately after establishing the bag & mask ventilation (T1), immediately after intubation (T2), 5 minutes after intubation (T3), 10 minutes after intubation (T4),at discharge(T5) & at 3months after discharge(T6).—

Countries

India

Contacts

Public ContactDr. Amiya Kumar Barik

PGIMER, Chandigarh

amiyabarik.scb@gmail.com8052919523

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026