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Vitamin D3 as local drug delivery therapy for gum disease

Evaluation of Clinical Efficacy of Locally Delivered Vitamin D3 Gel as an Adjunct to Nonsurgical Periodontal Therapy in the Treatment of Periodontitis - NIL

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/06/068312
Enrollment
26
Registered
2024-06-04
Start date
Unknown
Completion date
Unknown
Last updated
2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: LDD of Vitamin D3 gel as an adjunct to SRP: Non Surgical Periodontal therapy will be done in all selected patients. This trial being a split mouth study
the Scaling and root planing, will be followed by local delivery of 0.5 ml of Vitamin D3 insitu gel just once at the baseline appointment on the test group site. The intervention will be done just onc
the Scaling and root planing, will be followed by local delivery of o.5 ml of placebo gel just once at baseline on the control site.

Sponsors

None
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients should have at least 14 natural teeth in the oral cavity. 2. Patients with no history of allergies. 3. Patients who are diagnosed with generalized periodontitis of stages II and III (According to World Workshop of Periodontology, 2017 with bilateral periodontal pockets with probing pocket depth of between 4 and 6 mm

Exclusion criteria

Exclusion criteria: 1. Smokers 2. pregnant and lactating mothers. 3. Patients who received radiotherapy, chemotherapy or immunosuppressive treatment, systemic corticosteroids, and/or anticoagulants 30 days prior to intervention. 4. Patients with any systemic disease. 5. Patients under the influence of non-steroidal anti-inflammatory drugs (NSAIDS) or any other anti-inflammatory medications, antibiotics, or steroids that can alter the course of periodontitis progression and treatment.

Design outcomes

Primary

MeasureTime frame
The gingival index, bleeding on probing, pocket depth and clinical attachment level would be reduced in test group.Timepoint: Baseline, 3 months and 6 months of follow up

Secondary

MeasureTime frame
Patient reported Outcome measures and experiences with respect to test siteTimepoint: Baseline, 3 months and 6 months of follow up

Countries

Iceland

Contacts

Public ContactDr Pranjali Bawankar

Ranjeet Deshmukh Dental College and Research Centre, Nagpur

drpranjalibawankar@gmail.com9975128729

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026