Health Condition 1: N00-N99- Diseases of the genitourinary system
Conditions
Interventions
Control Intervention1: NIL: NIL as it is an observational study
Sponsors
AIIMS Bibinagar
Eligibility
Inclusion criteria
Inclusion criteria: All azoospermic male partners of infertile couples between =21-50 years of age and married for =1 year reporting to the infertility clinic will be enrolled as cases and all normozoospermic fertile men (=21-50 years) having one or more biological children will be enrolled as controls.
Exclusion criteria
Exclusion criteria: Renal/cardiovascular/liver diseases Diabetes mellitus Alzheimer disease Osteoporosis Hypoparathyroidism Prostate or testicular cancers Rheumatoid arthritis Inflammatory bowel disease Radiotherapy, chemotherapy Semen abnormalities other than azoospermia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.To assess, evaluate, and compare the serum and seminal levels of a-Klotho protein in azoospermic and normozoospermic men, 2.To assess, evaluate, and compare the serum and seminal PSA levels in azoospermic and normozoospermic men, 3.To establish the correlation between a-Klotho and PSA levels in semen and serum of azoospermic and normozoospermic men.Timepoint: During second visit. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.To explore the potential involvement of a-Klotho protein in the process of spermatogenesis, 2.To develop targeted treatment options for men with azoospermia, 3.To develop effective diagnostic markers for early diagnosis of azoospermia.Timepoint: After finalization of results. | — |
Countries
India
Contacts
Public ContactNaina Kumar
All India Institute of Medical Sciences, Bibinagar
Outcome results
None listed