Effect of low-dose intrathecal (within the spinal space) morphine as a part of multimodal analgesia (which combines various groups of medications for pain relief) in patients aged 18 to 65 years undergoing cardiac surgery by cutting of breast bone.

Effect of low dose intrathecal morphine as a part of multimodal analgesia in patients undergoing cardiac surgeries through sternotomy â?? open-label randomized control trial. - Nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/06/068299

Enrollment

104

Registered

2024-06-04

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I39- Endocarditis and heart valve disorders in diseases classified elsewhere

Interventions

Intervention1: INTRATHECAL MORPHINE: Single shot intrathecal 0.1 mg preservative free morphine will be given via 25 gauge Quincke needle either in the L2-L3 or L3-L4 intrathecal space by a midline app

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged 18 to 65 years undergoing midline sternotomy for cardiac surgeries, New York Heart Association grade II-III patients

Exclusion criteria

Exclusion criteria: Patient refusal to consent, contraindications to intrathecal analgesia such as infection at the injection site, coagulopathy, and allergy to morphine, pre-existing chronic pain: taking routine analgesics, patients with a history of chronic opiate abuse, patients with psychiatric disorders, patients with previous surgery in thoracic vertebral region, preexisting neurological condition (spinal cord injury, multiple sclerosis, etc.), patients with BMI more than or equal to 35, patients with severe respiratory disease, those expected to be on elective mechanical ventilation for more than 6 hours postoperatively, patients with renal dysfunction (Serum creatinine more than 1.5 mg/dl).

Design outcomes

Primary

Measure	Time frame
To assess postoperative pain by visual analogue scale (VAS) scoreTimepoint: upto 24 hour post-operative period	—

Secondary

Measure	Time frame
Total dose of opioids received in the postoperative period (at first 24 hour)Timepoint: upto 24 hour post-operative period;Time taken for the first dose of rescue analgesiaTimepoint: in first 24 hour post-operative period;To evaluate the incidence of any side effects such as respiratory depression, nausea and vomiting, pruritus, incidence of reintubation and sedationTimepoint: upto 24 hour post-operative period	—

Measure

Time frame

Total dose of opioids received in the postoperative period (at first 24 hour)Timepoint: upto 24 hour post-operative period;Time taken for the first dose of rescue analgesiaTimepoint: in first 24 hour post-operative period;To evaluate the incidence of any side effects such as respiratory depression, nausea and vomiting, pruritus, incidence of reintubation and sedationTimepoint: upto 24 hour post-operative period

—

Countries

India

Contacts

Public ContactAnil Gupta

All India Institute of Medical Sciences

subratsingh@gmail.com9406090235

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026