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Comparing granisetron with dexamethasone and ondansetron with dexamethasone as prophylaxis for postoperative nausea and vomiting in adults planned for elective laparoscopic surgery

Comparison Of Granisetron-Dexamethasone Combination and Ondansetron – Dexamethasone Combination As Prophylaxis For Postoperative Nausea And Vomiting In Adults Undergoing Elective Laparoscopic Surgery - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/06/068287
Enrollment
100
Registered
2024-06-04
Start date
Unknown
Completion date
Unknown
Last updated
2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K800- Calculus of gallbladder with acutecholecystitis Health Condition 2: R688- Other general symptoms and signs

Interventions

Control Intervention1: dexamethasone-granisetron: injection dexamethasone 8mg with injection granisetron 2mg is to be during induction of patient one time only Control Intervention2: dexamethasone-on

Sponsors

VARUN ARJUN MEDICAL COLLEGE
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients of age 18-60 years American Society of Anaesthesiologists (ASA) physical status I/II Planned for elective laparoscopic surgery under Spinal anesthesia or general anesthesia. undergoing elective lower abdominal surgeries under spinal anesthesia and general anesthesia. BMI 20 and 30 Kg/m2 The above patients who Provide written informed consent will be enrolled in the study

Exclusion criteria

Exclusion criteria: Patients with a history of PONV. severe cardiorespiratory, hepatic, renal, neurological or endocrinal disease, pregnant and lactating women, obesity diabetes mellitus

Design outcomes

Primary

MeasureTime frame
dexamethasone-granisetron COMBINATION prophylactically gives better protection than combination of dexamethason with ondansetron in POST OPERATIVE NAUSEA AND VOMINTING which is one of the side effect of laparoscopic surgery due to co2 insufflationTimepoint: 2 hours, 6 hours, 8 hours ,12 hours ,24 hours

Secondary

MeasureTime frame
we will also see the efficacy of both drugs in full 24 hour period that which will be resceive rescue drug which will sameTimepoint: 2 hours, 6 hours, 8 hours ,12 hours ,24 hours

Countries

India

Contacts

Public ContactLove Mehrotra

VARUN ARJUN MEDICAL COLLEGE AND ROHILKHAND HOSPITAL

mirbashir96@gmail.com9682536855

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026