A clinical trial to compare the effects of two different drugs, in patients suffering from various mental disorders and undergoing ECT for the same.

Efficacy of etomidate versus propofol on seizure duration and hemodynamics in patients undergoing modified ECT- a randomised cross over study - nil

Status

Recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/06/068273

Enrollment

Registered

2024-06-03

Start date

Unknown

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F319- Bipolar disorder, unspecified Health Condition 2: F28- Other psychotic disorder not due to a substance or known physiological condition Health Condition 3: F259- Schizoaffective disorder, unspecified Health Condition 4: F209- Schizophrenia, unspecified

Interventions

Intervention1: Intravenous inj etomidate to be given as induction agent.: Intravenous inj etomidate 0.2 mg/kg to be given as a single dose of induction, before applying electrical stimulus in patients

Eligibility

Inclusion criteria

Inclusion criteria: This study will be conducted on patients suffering from a mental disorder as per ICD 11 and requiring modified electroconvulsive therapy as per the decision of the consultant psychiatrist.

Exclusion criteria

Exclusion criteria: This study will be conducted on the following patients: patients with a history of relevant drug allergy. patients who have had prior treatment with ECT. patients with a history of substance abuse with relevant drugs. patients with anticipated difficult airway.

Design outcomes

Primary

Measure	Time frame
To compare the seizure duration produced with etomidate to that with propofol in patients undergoing modified ECT. Timepoint: From the time application of stimulus until the subsidence of convulsions, the normal range of convulsions induced being 15-100 seconds	—

Secondary

Measure	Time frame
To compare the effect on haemodynamics produced with Etomidate to that with Propofol in patients undergoing modified ECT, in terms of - 1.Heart rate , 2.Systolic blood pressure (SBP), 3.Diastolic blood pressure (DBP) , 4.Mean arterial pressure (MAP) 5.Oxygen saturation (spo2) and 6. EtCO2 Timepoint: 1.Heart rate 2.Systolic blood pressure 3.Diastolic blood pressure 4.Mean arterial pressure 5.Oxygen saturation (spo2) 6. EtCO2 will be recorded before induction (T0), after administration of study drug(T1), during the seizure activity(T2) & after 1(T3), 3(T4), 5(T5), & 10 min (T6) of seizure activity.	—

Measure

Time frame

To compare the effect on haemodynamics produced with Etomidate to that with Propofol in patients undergoing modified ECT, in terms of - 1.Heart rate , 2.Systolic blood pressure (SBP), 3.Diastolic blood pressure (DBP) , 4.Mean arterial pressure (MAP) 5.Oxygen saturation (spo2) and 6. EtCO2 Timepoint: 1.Heart rate 2.Systolic blood pressure 3.Diastolic blood pressure 4.Mean arterial pressure 5.Oxygen saturation (spo2) 6. EtCO2 will be recorded before induction (T0), after administration of study drug(T1), during the seizure activity(T2) & after 1(T3), 3(T4), 5(T5), & 10 min (T6) of seizure activity.

—

Countries

India

Contacts

Public ContactDevi Kulkarni

NKP Salve institute of medical sciences

bhargavasumita@yahoo.in7219105329

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026