Health Condition 1: N911- Secondary amenorrhea
Conditions
Interventions
Intervention1: Oral estradiol valerate along with oral medroxy progesterone acetate.: Oral estradiol valerate 2mg daily along with oral medroxy progesterone acetate 10mg from day 15- day 25.
Control
Sponsors
Guru Teg Bahadur Hospital
Eligibility
Inclusion criteria
Inclusion criteria: All the women below 40 yrs with newly diagnosed POI according to ESHRE guidelines
Exclusion criteria
Exclusion criteria: 1.Patient with chromosomal anomalies 2.Already receiving or have received hormone therapy. 3.Hormone therapy is contraindicated like in : a) Known case or history of breast cancer and uterine cancer. b) Active or history of deep venous thrombosis (DVT) or pulmonary embolism. c) History of clotting disorder d) Active or history of arterial thrombotic diseases such as myocardial infarction or stroke e) Chronic liver disease or dysfunction f) Migraine with aura 4. Have received non-hormonal treatment like SSRIs, Gabapentinoids or Neurokinin B for
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1)Comparison between the changes in clinical parameters among two groups after 6 months of HRT. 2)Comparison between changes in radiological parameters among two groups after 6 months of HRT. 3)Comparison between changes in biochemical parameters among two groups after 6 months of HRT.Timepoint: 6months | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of side effects of HRT among two group which will include liver function tests.Timepoint: 6 months. | — |
Countries
India
Contacts
Public ContactRitam Kumari
University College Of Medical Sciences And GTB Hospital
Outcome results
None listed