Comparing sugammadex and neostigmine for rapid and smooth recovery from anesthesia in intracranial lesion.

A comparison of sugammadex and neostigmine for rapidity and smoothness of reversal of neuromuscular blockade in patient undergoing excision of intracranial space-occupying lesions. A prospective randomized, double-blind, single-center study - NIL

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/06/068258

Enrollment

100

Registered

2024-06-03

Start date

Unknown

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: G939- Disorder of brain, unspecified

Interventions

Intervention1: Sugammadex or Neostigmine Methyl sulphate as reversal agent: Either Sugammadex or Neostigmine will be injected over 10 seconds for reversal of neuromuscular blockade of Vecuronium Bromi

Eligibility

Inclusion criteria

Inclusion criteria: 1. Elective Craniotomies pertaining to Intracranial space occupying lesions 2. ASA II to III

Exclusion criteria

Exclusion criteria: 1. Refusal to consent 2. Pediatric age group 3. Allergies to Study Drug 4. Neuro-degenerative, neuromuscular disorders 5. Pregnancy 6. Emergency surgery

Design outcomes

Primary

Measure	Time frame
Comparison of rapidity of reversal from neuromuscular blockade by using Sugammadex versus Neostigmine based on train of four ratio 0.8Timepoint: Starting from administration of reversal agent till extubation	—

Secondary

Measure	Time frame
Comparing hemodynamic events after reversal with sugammadex versus neostigmineTimepoint: till two hour after extubation;Secondary complication after reversal with sugammadex versus neostigmineTimepoint: Till two hours after extubation;Comparison of recovery from neuromuscular blockade using sugammadex versus neostigmineTimepoint: Time taken to achieve modified Aldrete score of 9/10 after extubation	—

Measure

Time frame

Comparing hemodynamic events after reversal with sugammadex versus neostigmineTimepoint: till two hour after extubation;Secondary complication after reversal with sugammadex versus neostigmineTimepoint: Till two hours after extubation;Comparison of recovery from neuromuscular blockade using sugammadex versus neostigmineTimepoint: Time taken to achieve modified Aldrete score of 9/10 after extubation

—

Countries

India

Contacts

Public ContactDr Gayatri Kumari

Life Line Hospital and Research Centre, Azamgarh

reply2gayatri@gmail.com9451243071

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026