Comparative study of Titanium Platelet-Rich Fibrin (T-PRF) and Leucocyte and Platelet-Rich Fibrin (L-PRF) in the treatment of intra-bony defects in chronic periodontitis patients

Comparative evaluation of Titanium Platelet-Rich Fibrin (T-PRF) versus Leucocyte and Platelet-Rich Fibrin (L-PRF) in the treatment of intra-bony defects in patients with chronic periodontitis: A Clinico-Radiological study - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/06/068255

Enrollment

Registered

2024-06-03

Start date

Unknown

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Titanium Platelet-Rich Fibrin: Titanium Platelet-Rich Fibrin (T-PRF) as autogenous graft to fill the intrabony defect in case (test) group for a total period of intervention being 9 mon

Eligibility

Inclusion criteria

Inclusion criteria: 1.Systemically healthy patient 2.Pocket depth =5 mm 3.Clinical attachment level = 3mm 4.Confirmation of at least one favorable intrabony defect of =3 mm radiographically 5.With plaque and gingival indices (GI and PI) of =1 6.Patients with at least 20 remaining teeth 7.Willing to comply with the study related procedures

Exclusion criteria

Exclusion criteria: 1.Chronic Smokers 2.Pregnant and Lactating women 3.Patients with any history of systemic diseases/conditions e.g. uncontrolled Diabetes Mellitus, chronic Rheumatoid arthritis, steroid therapy, autoimmune diseases etc. 4.Patient who have received a history of periodontal surgery within one year 5.Patients on antibiotic therapy from past 1 month

Design outcomes

Primary

Measure	Time frame
To compare changes radiographically using IOPA in the measurement of bone fill after flap operation, in Titanium platelet-rich fibrin (T-PRF) over Leucocyte & platelet-rich fibrin (L-PRF)Timepoint: At Baseline, At Six month, At Nine month	—

Secondary

Measure	Time frame
•Describe the changes clinically after flap operation, in Titanium platelet-rich fibrin (T-PRF) & Leucocyte & platelet-rich fibrin (L-PRF) - in clinical attachment level (CAL) - in probing pocket depth (PPD) - in gingival index (GI) - in plaque index (PI) •Describe the changes radiographically using CBCT, in the density of bone fill after flap operation, in Titanium platelet-rich fibrin (T-PRF) and Leucocyte and platelet-rich fibrin (L-PRF) Timepoint: At Baseline, At Six month, At Nine month	—

Measure

Time frame

•Describe the changes clinically after flap operation, in Titanium platelet-rich fibrin (T-PRF) & Leucocyte & platelet-rich fibrin (L-PRF) - in clinical attachment level (CAL) - in probing pocket depth (PPD) - in gingival index (GI) - in plaque index (PI) •Describe the changes radiographically using CBCT, in the density of bone fill after flap operation, in Titanium platelet-rich fibrin (T-PRF) and Leucocyte and platelet-rich fibrin (L-PRF) Timepoint: At Baseline, At Six month, At Nine month

—

Countries

India

Contacts

Public ContactDr Brajesh Kumar

Armed Forces Medical College

cd44_mmm@yahoo.co.in9837692014

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026