A Trial Comparing The Efficacy Of Combination Of Low Dose Of Dexmedetomidine And Bupivacaine 0.0625% With Plain Bupivacaine 0.125% In Postoperative Pain Management And Recovery In Abdominal And Lower Limb Surgeries

An Open Label Randomised Trial Comparing Low Dose Of Dexmedetomidine As An Adjuvant To Isobaric Bupivacaine 0.0625% In Comparison With Plain Bupivacaine 0.125% To Assess Quality Of Postoperative Analgesia And Recovery In Abdominal And Lower Limb Surgeries - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/05/068224

Enrollment

Registered

2024-05-31

Start date

Unknown

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring

Interventions

Intervention1: DEXMEDETOMIDINE And BUPIVACAINE: 0.5 mcg/kg DEXMEDETOMIDINE And 0.0625% BUPIVACAINE for 24 hours Control Intervention1: BUPIVACAINE: 0.125% BUPIVACAINE infusion for 24 hours

Eligibility

Inclusion criteria

Inclusion criteria: Abdominal and lower limb surgeries ASA grade 1 and 2 Adults

Exclusion criteria

Exclusion criteria: Bleeding disorders and coagulopathies Pregnancy raised ICT Altered sensorium Preexisting Bradycardia Hypotension

Design outcomes

Primary

Measure	Time frame
Quality of analgesia using subjective tool-VAS scale and objective pain assessment tool- salivary alpha amylase levelTimepoint: 0 HR 1 HR 2 HR 6 hr 12 hr 24 hr	—

Secondary

Measure	Time frame
Degree Of Motor BlockTimepoint: 0 hr 2 hr 6 hr 12 hr 24 hr ;Hemodynamic instability(pulse rate, mean arterial BP ,respiratory rate, Ritchmond Almond Sedation scale ,spo2)Timepoint: 0 hr ,2 hrs ,6 hrs , 12 hrs, 24hrs;Incidence of adverse effectsTimepoint: Upto 24 hrs;Requirement Of Rescue AnalgesicTimepoint: upto 24 hours	—

Countries

India

Contacts

Public ContactNayana Sabu

AIIMS NAGPUR

nayana0016@gmail.com8848087592

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026