Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: commercially prepared coconut water: 30 gm of commercially prepared (prepared using flash freeze technique, preservative free) coconut powder containing 13 gm of carbohydrate will be gi
Sponsors
Internal Fluid Research Grant
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1. Age group 18-65 years 2. Patients undergoing elective, minor (level 2), intermediate (level 3) or high risk (level 4) abdominal surgeries involving upper and lower gastrointestinal tracts, hepatic resection or biliary reconstruction. 3. Patients undergoing inguinal, umbilical or incisional hernia repair. 4. All ASA1 and ASA 2 patients undergoing the above-mentioned surgeries who do not meet the exclusion criteria.
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1. Patients having conditions that impair gastric emptying time – GERD, obesity, pregnancy, gastric outlet obstruction, intestinal obstruction, patients on certain pharmacological agents (like Morphine, tricyclic antidepressants, Levo-dopa) or patients who are unable to tolerate oral diet. 2. Patients having conditions affecting blood sugar level/ insulin level/ patient prone for dyselectrolytaemia – Diabetes Mellitus, Chronic Kidney Disease, Pancreatic tumor, or tumor involving pancreatic resection, adrenal insufficiency, or patients receiving colonic preparation prior to surgery. 3. Conditions that can affect the inflammatory markers- patients with sepsis, emergency procedures, and those undergoing oncological surgeries. 4. Patients undergoing very low risk (level 1) or very high risk (level 5) elective abdominal surgeries. 5. ASA 3, ASA 4 and ASA 5 patients. 6. Conditions that can affect glucose homeostasis- chronic liver disease, hyperthyroidism, HIV-AIDS, patients on steroid therapy. 7. Pregnant and lactating mothers. 8. Patients with BMI less than 18 or more than 30.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare insulin resistance between two groups- one receiving carbohydrate rich preparation and the other receiving coconut water preparation, using HOMA-IR method (Homeostatic Model Assessment- Insulin Resistance), LAP index (Lipid Accumulation Product index) and TyG index (Triglyceride -Glucose Index) – before and after carbohydrate loading.Timepoint: The outcome will be assessed at - baseline (fasting) and - 2 hours after pre-loading with the drink (post-prandial). It will be assessed on the same day, 2 hours apart. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To compare C-Peptide levels before & after carbohydrate loading in two groups- one receiving carbohydrate rich preparation & the other receiving coconut water preparation. 2. To compare the psychosomatic status of the patients before & after receiving carbohydrate loading in the two groups using Visual Analogue Scale (VAS Scale) – anxiety, hunger, thirst, dryness of mouth, fatigue, headache, nausea, pain.Timepoint: The outcomes will be assessed at - baseline (fasting) & - 2 hours after pre-loading with the drink (post-prandial). It will be assessed on the same day, 2 hours apart. | — |
Countries
India
Contacts
Public ContactDr Borna Das
Christian Medical College Vellore
Outcome results
None listed