Comparison of magnesium sulphate and placebo on neuromuscular blockade reversal during emergence from anaesthesia in patients undergoing general anaesthesia for elective surgery.

Effect of Magnesium sulphate on Vecuronium induced neuromuscular blockade reversal using Neostigmine: A randomized, single-blind study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/05/068151

Enrollment

154

Registered

2024-05-31

Start date

Unknown

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Magnesium sulphate: Dose - 2g of magnesium sulphate in 100mL of 0.9% normal saline Route - Intravenous (I.V) Duration - Slowly over 10 minutes Frequency - Only once, 15 mintues before i

Eligibility

Inclusion criteria

Inclusion criteria: 1. BMI 18.5 - 29.99 kg/sq metre 2. ASA physical status 1 and 2

Exclusion criteria

Exclusion criteria: 1. Patient refusal 2. Hyper and hypomagnesemia 3. Pregnancy 4. Cardiac disease 5. Neuromuscular disease (myasthenia gravis, muscular dystrophy, upper motor neuron lesions) 6. Special group of population (notified tribals, jail inmates, etc)

Design outcomes

Primary

Measure	Time frame
To compare the duration of neuromuscular reversal time (by NMT monitoring) of magnesium sulphate and placebo groups. Parameters - 1. Train-of-four count (TOFC), 2. Train-of-four ratio (TOFR)Timepoint: 15 minutes before intubation, 10 minutes before intubation, 5 minutes before intubation, Immediately after intubation, 5 minutes, 10 minutes, 15 minutes, 30 minutes, 45 minutes, 60 minutes, and so on.	—

Measure

Time frame

To compare the duration of neuromuscular reversal time (by NMT monitoring) of magnesium sulphate and placebo groups. Parameters - 1. Train-of-four count (TOFC), 2. Train-of-four ratio (TOFR)Timepoint: 15 minutes before intubation, 10 minutes before intubation, 5 minutes before intubation, Immediately after intubation, 5 minutes, 10 minutes, 15 minutes, 30 minutes, 45 minutes, 60 minutes, and so on.

—

Secondary

Measure	Time frame
1. To compare the shifting time from OT to PACU of the two groups 2. To compare the need of supplemental vecuronium dose requirement among the groups.Timepoint: Time of reversal administration, 1 min after reversal, 2 mins, 3 mins, 4 mins, 5 mins, 10 mins, 15 mins, 20 mins.	—

Countries

India

Contacts

Public ContactDipak Bhuyan

All India Institute of Medical Sciences, Deoghar

drsanjayaiims2012@gmail.com7063956225

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Sep 19, 2026