To compare intra operative intravenous Dexmemeditomine versus Fentanyl for attenuating hemodynamic response in laproscopic cholecystectomy.

Comparison of intra operative intravenous dexmedetomidine versus fentanyl for attenuating hemodynamic response in laparoscopie cholecystectomy randomized interventional study in the department of anaesthesiology sms medical college and attached group of hospitals - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/05/068122

Enrollment

Registered

2024-05-30

Start date

Unknown

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K00-K95- Diseases of the digestive system Health Condition 2: O- Medical and Surgical Health Condition 3: K358- Other and unspecified acute appendicitis

Interventions

Intervention1: Intravenous Dexmedetomidine: Patients will receive intravenous 0.5 µg/kg of the Dexmedetomidine as loading dose over 10 minutes prior to intubation followed by 0.2-0.7 µg/kg/hr as infus

Eligibility

Inclusion criteria

Inclusion criteria: ASA Grade I & II BMI: 18.5 to 25 Patients bodyb weight 40-70 kgs Undergoing elective laproscopic cholecystectomy Patients willing to give consent

Exclusion criteria

Exclusion criteria: Patients allergic to the study drugs Patients with anticipated difficult airway and laryngoscopytime more than 30 seconds Patients on beta blocker

Design outcomes

Primary

Measure	Time frame
To determine the hemodynamic variation from baseline in both the groups in terms of difference in mean HR at different time intervals. Timepoint: 0 BASE line 10 minutes after the study drug After inj. Of induction drug Immediately After intubation 1min after intubation 2min after intubation 5min after intubation Immediately after pneumoperitoneum 1min 5min 15min 30min 60 min 5 min after release of pneumoperitoneum Immediately post extubation 1 min 2 min 5 min 10 min	—

Measure

Time frame

To determine the hemodynamic variation from baseline in both the groups in terms of difference in mean HR at different time intervals. Timepoint: 0 BASE line 10 minutes after the study drug After inj. Of induction drug Immediately After intubation 1min after intubation 2min after intubation 5min after intubation Immediately after pneumoperitoneum 1min 5min 15min 30min 60 min 5 min after release of pneumoperitoneum Immediately post extubation 1 min 2 min 5 min 10 min

—

Secondary

Measure	Time frame
TO DETERMINE CHANGE IN SBP DBP ETCO2 serum cortisol in response to pneumoperitoniumTimepoint: 10 min before surgery to 5 min post extubation	—

Countries

India

Contacts

Public ContactDr Virendra Singh Meena

sms medical college

chatterjee.chandrashekhar@gmail.com9828088092

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026