Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Inj. Dexmedetomidine at 0.5 mcg/kg/hour: Inj. Dexmedetomidine at 0.5 mcg/kg/hour in Group D(DEXMEDETOMIDINE) given after induction till end of surgery
Control Intervention1: Inj. 0.9% N
Sponsors
Iti Shri
Eligibility
Inclusion criteria
Inclusion criteria: diabetic patients with HbA1c less than or equal to 8% with fasting blood sugar of less than 150mg/dl ejection fraction of more than 50% undergoing elective off pump coronary artery bypass grafting(CABG)
Exclusion criteria
Exclusion criteria: diabetic patients with HbA1c more than 8% with fasting blood sugar of more than 150mg/dl,emergency CABG,CABG done on cardiopulmonary bypass or if intraoperative pump conversion, CABG done with other heart surgeries, anemia with preoperative Hb less than 10g%, Hepatic dysfunction, patients on preoperative steroids, an endocrine disorder with hypercortisolism, bradycardia due to any reason, any active infection, patient critically ill like on mechanical ventiation or inotropes or intra aortic balloon pump
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the effect of injection dexmedetomidine on blood glucose variabilityTimepoint: After induction till 24 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.To assess the level of inflammatory markers viz.IL-6 and CRP at preinduction, and at 12 hours and 24 hours postoperatively. 2.To assess and compare mean insulin requirement between the groups.Timepoint: 24 hours postoperatively | — |
Countries
India
Contacts
Public ContactIti Shri
ABVIMS and Dr. RML Hospital, New Delhi
Outcome results
None listed