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Study to assess effect of ethanol locking solution in treating tunneled Catheter related blood stream infections

A Randomised Controlled Study To Assess The Catheter Salvageability By Ethanol Locking With Intravenous Antibiotics Versus Intravenous Antbiotics Alone In Tunneled Catheter Related Blood Stream Infection. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/05/068066
Enrollment
76
Registered
2024-05-29
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: A499- Bacterial infection, unspecified

Interventions

Intervention1: Ethanol locking: Ethanol-lock therapy Daily ethanol-lock with 70% ethanol instilled in device dead-space, left in place for 4hrs daily, Emprical antibioitcs is given Lock therapy will

Sponsors

ABVIMS AND RML INSTITUTE
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: CKD with tunneled catheter infections with case surveillance definition Fever Intra dialytic chills

Exclusion criteria

Exclusion criteria: 1. Acute kidney injury and Acute kidney disease 2. Blood culture positivity for fungal and mycobacterial infections at presentation. 3. Patients presenting with shock refractory to fluid therapy requiring inotropes. 4. Pregnancy 5. Known other source of infection. 6. Allergic to alcohol. 7. Focus of infection in another sites. 8. Infection in the tunnel.

Design outcomes

Primary

MeasureTime frame
Salvegeability rates of catheter in each arm,Timepoint: Salvegeability rates of catheter in each arm day7—

Secondary

MeasureTime frame
1.Time for the next relapse & recurrence on Day 30 & Day 60. 2.Persistence of Bacteremia [ Time Frame: 7 days & 15 days] 3.Clinical, microbiological & antibiogram profile of tunneled catheter infections. 4.Mortality rate related to catheter related blood stream infections. (Day 60) 5.Catheter dysfunction like catheter related thrombosis, mechanical wear & tear. (day 60) Timepoint: 1. Time Frame 30 Days & 60 days 2. Time frame day 7 & day 15 3. Time frame day 30 4.Time frame till day 30 5.Time frame till day 30—

Countries

India

Contacts

Public ContactHARI PRASAD MK

Atal Bihari Vajpayee Institute of Medical Science and Ram Manohar Lohia Hospital

drlalitkpursnani@gmail.com09958268930

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026