Study compares inhaling (nebulized) vs. vein injection (IV) of magnesium sulphate in high blood pressure patients under general anesthesia. It assesses which method better controls blood pressure, heart rate during intubation

Comparison between nebulized and intravenous form of magnesium sulphate for attenuation of hemodynamic response during endotracheal intubation in hypertensive patients undergoing general anesthesia : A randomized controlled study - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/05/068060

Enrollment

100

Registered

2024-05-29

Start date

Unknown

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Nebulized form of magnesium sulphate: During general anesthesia, hypertensive patients will receive nebulization magnesium sulphate to help control their hemodynamic response to intubat

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1 and 2 MPC grade 1 and 2

Exclusion criteria

Exclusion criteria: Patients with anticipated difficult airway History of ischemic heart disease Pregnancy

Design outcomes

Primary

Measure	Time frame
The nebulized form of magnesium sulphate will demonstrate comparable efficacy to the intravenous administration in attenuating the stress response during physiological challenges such as endotracheal intubationTimepoint: Heart rate , Systolic blood pressure, Diastolic blood pressure, Mean arterial pressure will be recorded at P0 - prenebulisation P1 - post nebulistion M0 - before IV magnesium sulphate M1 - after IV magnesium sulphate I1 - post induction T1 - post intubation T2 - 2 min after intubation T3 - 5 min after intubation T4 - 10 min after intubation	—

Measure

Time frame

The nebulized form of magnesium sulphate will demonstrate comparable efficacy to the intravenous administration in attenuating the stress response during physiological challenges such as endotracheal intubationTimepoint: Heart rate , Systolic blood pressure, Diastolic blood pressure, Mean arterial pressure will be recorded at P0 - prenebulisation P1 - post nebulistion M0 - before IV magnesium sulphate M1 - after IV magnesium sulphate I1 - post induction T1 - post intubation T2 - 2 min after intubation T3 - 5 min after intubation T4 - 10 min after intubation

—

Secondary

Measure	Time frame
Time taken to administer first maintenance dose of muscle relaxantsTimepoint: 30 minutes from the loading dose of muscle relaxants	—

Countries

India

Contacts

Public ContactDr Gayatri B

SRM Medical College Hospital and Research institute

gayathrii.r@gmail.com9500092905

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026