comparison between intravenous dexmedetomidine and magnesium sulphate in producing hypotensive anesthesia in patients undergoing Functional endoscopic sinus surgeries

A comparative study to evaluate the efficacy between intravenous Dexmedetomidine and Magnesium sulphate for controlled hypotension during Functional Endoscopic Sinus Surgery: A randomized double blinded controlled trial - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/05/068035

Enrollment

100

Registered

2024-05-29

Start date

Unknown

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J329- Chronic sinusitis, unspecified Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: HYPOTENSIVE ANAESTHESIA: comparing and evaluate the efficacy of two drugs in producing hypotensive anaesthesia for patient undergoing FESS surgeries Control Intervention1: DEXMEDETOMID

Eligibility

Inclusion criteria

Inclusion criteria: ASA-physical status I and II. patients undergoing Functional Endoscopic Sinus Surgeries.

Exclusion criteria

Exclusion criteria: Patient refusal. Patients with severe cardiac hepatic renal disease. Patients with a history of drug allergy to the study drugs. Patients with hemodynamic instability. Patients with coagulopathies. Pregnant patients. Patients with autonomic dysfunction. Patients on magnesium supplementation. Patients with electrolyte abnormality. Patients with Anti-arrhythmic drugs & Anti-hypertensive drugs.

Design outcomes

Primary

Measure	Time frame
To compare the efficacy of Dexmedetomidine vs Magnesium sulphate in providing controlled hypotension during Functional Endoscopic Sinus Surgeries. By means of monitoring MAP mean arterial pressure throughout the procedure.Timepoint: 2 hours	—

Secondary

Measure	Time frame
Clinical signs related to study drugsTimepoint: 2 hours;Time of Requirement of 1st rescue analgesia VAS score.Timepoint: 2 hours;Time to reach adequate Modified Aldrete scoreTimepoint: 20 minutes;To assess the level of bleeding during procedure Boezaart & Van der merwe score. Timepoint: 2 hours;To assess the level of sedation of the patient post operatively Ramsay Sedation Score.Timepoint: 2 hours;To assess the surgeons satisfaction during procedure Likert scoreTimepoint: 2 hours	—

Measure

Time frame

Clinical signs related to study drugsTimepoint: 2 hours;Time of Requirement of 1st rescue analgesia VAS score.Timepoint: 2 hours;Time to reach adequate Modified Aldrete scoreTimepoint: 20 minutes;To assess the level of bleeding during procedure Boezaart & Van der merwe score. Timepoint: 2 hours;To assess the level of sedation of the patient post operatively Ramsay Sedation Score.Timepoint: 2 hours;To assess the surgeons satisfaction during procedure Likert scoreTimepoint: 2 hours

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Countries

India

Contacts

Public ContactDr C rajesh prabhu

Aarupadai veedu medical college and hospital

haribabu.veeraraghavan@avmc.edu.in9442369647

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026