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To study the disease causing gene involved in gum and surrounding bone disease of teeth

Evaluation of the association of ALOX15 gene polymorphism in patients with periodontitis -a case -control study - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/05/068026
Enrollment
162
Registered
2024-05-29
Start date
Unknown
Completion date
Unknown
Last updated
2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: nil: nil

Sponsors

RAKSHA R
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Systemically healthy patients of age 30-60 are to be recruited for the study. 2. Ethnic Tamilian subjects. 3. Control group to include subjects with no signs of periodontal disease and probing sulcus depth of = 3mm with no evidence of clinical attachment loss. 4. Test group to include patients with Probing Pocket Depth of = 5mm and/or Clinical Attachment Loss of =3mm in greater than 30% of sites with periodontitis. (Stage II/III Periodontitis)

Exclusion criteria

Exclusion criteria: 1. Patients with any inflammatory systemic conditions such as diabetes mellitus, rheumatoid arthritis, etc. 2. Patients with immunodeficiency disorders. 3. Patients with local modifiers like food impaction, factitious habits and bruxism. 4. Patients who smoke. 5. Use of orthodontic and prosthetic appliances. 6.Patients who had taken systemic antibiotic, antiinflammatory,hormonal or other assisted drug therapy in the last 6 months or prior to the study.

Design outcomes

Primary

MeasureTime frame
1)distribution of genotype and allele frequencies are to be assessed 2) Plaque Index -PI (Loe and silness,1964) 3)Modified Sulcular bleeding index -mSBI (Mombelli, 1987) 4) Probing pocket depth (PPD) 5) Clinical attachment level (CAL)Timepoint: baseline

Secondary

MeasureTime frame
nilTimepoint: nil

Countries

India

Contacts

Public ContactDR S SANGEETHA

SRM DENTAL COLLEGE RAMAPURAM

sangeetha_doc@yahoo.com9884563217

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026