Effect of combined paracetamol and dexamathasone on post operative nausea and vomiting in patients undergoing elective functional endoscopic sinus surgery.

A prospective randomized double blinded study - Effect of combined paracetamol and dexamethasone on post operative nausea and vomiting. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/05/068021

Enrollment

120

Registered

2024-05-29

Start date

Unknown

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H958- Other intraoperative and postprocedural complications and disorders of the ear and mastoid process, not elsewhere classified Health Condition 2: H578- Other specified disorders of eye and adnexa

Interventions

Intervention1: paracetamol with dexamethasone: paracetamol 30ml/kg is given intravenously along with dexamethasone 0.1mg/kg intravenously before induction once. The duration of the intervention is obs

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA 1 to 2 2. All Elective FESS surgery 3. All procedures done under General anaesthesia with a duration of less than 3 hours 4. Willingness to participate in the study

Exclusion criteria

Exclusion criteria: 1. Patient’s refusal to give consent 2. Allergy to paracetamol, ondansetron 3. Emergency cases 4. ASA 3 and above 5. Patients requiring admission to the intensive care unit or mechanical ventilation 6. Surgery duration more than 3 hours 7. Patients with history of gastroesophageal reflux disorder, peptic ulcer disease, inflammatory bowel disease. 8. Patients with history of PONV, systemic diseases with nausea and vomiting 9. Patients requiring opioids in the post operative period

Design outcomes

Primary

Measure	Time frame
incidence of post operative nausea and vomitingTimepoint: 1) incidence of nausea and vomiting is assessed from 1 minute after induction till the entire surgery and 12 hours post operatively 2) severity of nausea and vomiting is assessed from 1 minute after induction till the entire surgery and 12 hours post operatively 3) need for rescue antiemetics is assessed from 1 minute after induction till the entire surgery and 12 hours post operatively	—

Measure

Time frame

incidence of post operative nausea and vomitingTimepoint: 1) incidence of nausea and vomiting is assessed from 1 minute after induction till the entire surgery and 12 hours post operatively 2) severity of nausea and vomiting is assessed from 1 minute after induction till the entire surgery and 12 hours post operatively 3) need for rescue antiemetics is assessed from 1 minute after induction till the entire surgery and 12 hours post operatively

—

Secondary

Measure	Time frame
incidence of post operative painTimepoint: 1) incidence of pain is assessed from 1 minute after induction till the entire surgery and 12 hours post operatively 2) severity of pain is assessed from 1 minute after induction till the entire surgery and 12 hours post operatively 3) need for rescue analgesics is assessed from 1 minute after induction till the entire surgery and 12 hours post operatively	—

Measure

Time frame

incidence of post operative painTimepoint: 1) incidence of pain is assessed from 1 minute after induction till the entire surgery and 12 hours post operatively 2) severity of pain is assessed from 1 minute after induction till the entire surgery and 12 hours post operatively 3) need for rescue analgesics is assessed from 1 minute after induction till the entire surgery and 12 hours post operatively

—

Countries

India

Contacts

Public ContactArul Murugan

Sri Ramachandra Institute of Higher Education and Research, Porur

rampond@gmail.com8072574147

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026