Study comparing the intravenous Lignocaine and Dexmedetomidine infusions as anaesthesia adjuvant for spine surgerys with regards to monitoring of the spinal cord function in neuromonitoring cases

Comparing the effect of lignocaine infusion on motor evoke potential (MEP) with dexmedetomidine infusion in intraoperative neuromonitoring cases - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/05/067977

Enrollment

164

Registered

2024-05-28

Start date

Unknown

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: The effect of lignocaine infusion on motor evoke potential in spine cases: Lignocaine has been used as an adjuvant to inhalational anesthesia to measure the motor evoke potential in spi

Eligibility

Inclusion criteria

Inclusion criteria: Patients scheduled for spine surgery with normal motor power Grade of 5. Patients with ASA grade 1,2,3

Exclusion criteria

Exclusion criteria: Any patients with an allergy to lignocaine.Any patient for emergency surgery.

Design outcomes

Primary

Measure	Time frame
Compare the Lignocaine infusion and Dexmedetomidine infusion on Motor evoked potential during intraoperative neuromonitoring Timepoint: The measurement of motor evoke potential after 30 minutes initial bolus of infusion. Then subsequent measurement immediately after positioning prone and 30 minutes and one hour of surgery, The time interval between the stoppage of the infusion and patient response to call also will ne taken	—

Measure

Time frame

Compare the Lignocaine infusion and Dexmedetomidine infusion on Motor evoked potential during intraoperative neuromonitoring Timepoint: The measurement of motor evoke potential after 30 minutes initial bolus of infusion. Then subsequent measurement immediately after positioning prone and 30 minutes and one hour of surgery, The time interval between the stoppage of the infusion and patient response to call also will ne taken

—

Secondary

Measure	Time frame
Dose of intraoperative fentanyl,hemodynamic variables,awakening time from end of infusion.Timepoint: dose of fentanyl and isoflurane at end of surgery haemodynamic variables 3,5 minutes after bolus and after positioning then every 30 minutes.Time taken to awake after infusion	—

Countries

India

Contacts

Public ContactEldo Issac

Amrita Institute of Medical Sciences

sundarambalaji143@gmail.com04872856162

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026