Health Condition 1: D582- Other hemoglobinopathies Health Condition 2: D57- Sickle-cell disorders Health Condition 3: D56- Thalassemia
Conditions
Interventions
Intervention1: NIL: NIL
Sponsors
All India Institute of Medical Sciences (AIIMS), Rajkot
Eligibility
Inclusion criteria
Inclusion criteria: Suspected cases of thalassaemia syndromes or hemoglobinopathies of any age range Patients found to have persistent microcytic hypochromic anaemia with low Mentzer index on CBC Antenatal cases and their family members who want to undergo prenatal testing for thalassaemia syndromes or hemoglobinopathies Voluntary cases of premarital testing for thalassaemia syndromes or hemoglobinopathies Patients having a positive family history of thalassaemia syndromes or hemoglobinopathies Suspected cases of chronic anemias or thalassaemia syndromes or hemoglobinopathies requiring occasional RBC transfusions clinical suspected thalessemia minor or intermedia
Exclusion criteria
Exclusion criteria: Known cases of thalassaemia syndromes or hemoglobinopathies In any suspected case of thalassaemia syndromes or hemoglobinopathies sampling will be deferred for at least 4 week after transfusion
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Carrier identification in family would be useful to create awareness and offer them compatible partner selection and prenatal diagnosisTimepoint: 3 months Data compilation and statistical analysis | — |
Primary
| Measure | Time frame |
|---|---|
| RBC indices RBC histograms along with clinical findings & family history can help in predicting the diagnosis various types of thalassemic syndromes and hemoglobinopathies by HPLC Hence complete blood counts comprising of RBC indices and RBC histograms can be used for triaging patients who require HPLC testing for confirmation of the diagnosisTimepoint: 1 year and 9 months from the date of approval Data collection of clinical findings and test results of cases | — |
Countries
India
Contacts
Public ContactGarima Anandani
All India Institute of Medical Sciences (AIIMS), Rajkot
Outcome results
None listed