Health Condition 1: K740- Hepatic fibrosis
Conditions
Interventions
Intervention1: Terlipressin: Intravenous infusion, with dosages starting at 3 mg every twenty four hour infusion.
Control Intervention1: Nor adrenaline: Initial starting dose will be calculated by pat
Sponsors
Department of GI Surgery Amrita Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Patient diagnosed withHRS-AKI at our hospital. The following inclusion criteria were applied: 1. Age between 18 and 70 years; 2. Satisfying the revised diagnostic criteria of HRS listed by the International Ascites Club, namely, cirrhosis with ascites; 3. Acute kidney injury according to new International Club of Ascites Criteria. 4. Absence of renal function recovery(return of serum creatinine to a final value upto 0.3mg/dL above the baseline) that did not improve within 48 hours of diuretic withdrawal and volume expansion with albumin; 5. Absence of shock; 6. No current or recent treatment with nephrotoxic drugs; 7. No findings of parenchymal renal disease(suggested by proteinuria >500mg/24hours or hematuria >50 RBC/HPF) or obstructive uropathy on laboratory and ultrasound assessment;
Exclusion criteria
Exclusion criteria: 1. History of coronary disease; 2. Evidence of ventricular arrhythmia or cardiomyopathy obtained based on history taking, risk factor evaluation, physical examination, echocardiography, and radiography. 3. History of adverse effects to any of these drugs or allergic to terlipressin. 4. Patient on Ionotropic supports. 5. Non HRS-AKI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| and rapid improvement in renal function (reduction in serum creatinine levels, increase in creatinine clearance & urine output), as well as by a large increase in Mean arterial pressure and serum sodium concentrationTimepoint: 48 hrs after treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Mortality as well as progression of patients to Liver Transplantation 2.Cost effectiveness Timepoint: Post 48 hrs | — |
Countries
India
Contacts
Public ContactMallika Singh
Amrita Institute of Medical Sciences and Research Centre
Outcome results
None listed