Effect of 1% Metformin gel on bone density.

Comparative evaluation of bone density in posterior maxilla in patients treated with dental implants alone, dental implants with 1% metformin gel coating and dental implants with 1% metformin gel coating along with CGF- A clinico-radiographic study - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/05/067922

Enrollment

Registered

2024-05-27

Start date

Unknown

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K068- Other specified disorders of gingiva and edentulous alveolar ridge

Interventions

Intervention1: 1% metformin gel coating around dental implants during placement: Dental implant coated with 1% metformin gel coating will be placed in posterior region of maxilla Intervention2: 1% met

Eligibility

Inclusion criteria

Inclusion criteria: Patient aged between 20 and 55 years Patient having edentulous space in maxillary posterior region Patients having good general and systemic health Co-operative, motivated and hygiene conscious patients

Exclusion criteria

Exclusion criteria: Patients requiring direct or indirect sinus lift procedures Patients with active infection or severe inflammation at planned implant site Patients under treatment with drugs which significantly impact periodontal inflammation and bone turnover Alcoholics, Smokers and patients with poor oral hygiene Patients with severe clenching and grinding Pregnant or lactating females

Design outcomes

Primary

Measure	Time frame
To evaluate and compare the effects on bone density in posterior maxilla in patients treated with dental implants alone, dental implants with 1% metformin gel coating and dental implants with 1% metformin gel coating along with CGFTimepoint: baseline, 3 , 6 and 9 months	—

Secondary

Measure	Time frame
To evaluate and compare crestal bone height, buccal bone thickness, ridge width and vertical distance in patients treated with dental implants alone, dental implants with 1% metformin gel coating and dental implants with 1% metformin gel coating along with CGFTimepoint: baseline and 9 months;To evaluate and compare modified plaque index, sulcular bleeding index, implant sulcus depth, gingival thickness and ridge width in patients treated with dental implants alone, dental implants with 1% metformin gel coating and dental implants with 1% metformin gel coating along with CGFTimepoint: baseline, 3 ,6 and 9 months	—

Measure

Time frame

To evaluate and compare crestal bone height, buccal bone thickness, ridge width and vertical distance in patients treated with dental implants alone, dental implants with 1% metformin gel coating and dental implants with 1% metformin gel coating along with CGFTimepoint: baseline and 9 months;To evaluate and compare modified plaque index, sulcular bleeding index, implant sulcus depth, gingival thickness and ridge width in patients treated with dental implants alone, dental implants with 1% metformin gel coating and dental implants with 1% metformin gel coating along with CGFTimepoint: baseline, 3 ,6 and 9 months

—

Countries

India

Contacts

Public ContactDr Abhay Kolte

Ranjeet Deshmukh Dental college and Research Center

drabhaypkolte@gmail.com9011071467

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026