To evaluate the healing outcome with human amniotic membrane, hydroxyapatite graft and laser biostimulation in patients having periapical lesion.

Comparative Analysis of Periapical Healing with Human Amniotic Membrane, Hydroxyapatite Graft and Laser Biostimulation in Peri Radicular Surgery Cases-A CBCT Study - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/05/067868

Enrollment

Registered

2024-05-24

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K049- Other and unspecified diseases ofpulp and periapical tissues

Interventions

Intervention1: Human amniotic membrane and Laser biostimulation on patient having periapical lesion.: This group will evaluate the healing after placement of human amniotic membrane followed by laser

Eligibility

Inclusion criteria

Inclusion criteria: 1.18 to 40 years of age 2.Teeth with Periapical Radiolucency indicated for surgery. 3.Patient not on any medication affecting periapical healing. (Corticosteroids, chemotherapeutic agents, Anticoagulants, drugs which reduce osteoclastic activity.) 4.Noncontributory medical history (ASA I & II). 5.Single rooted anterior teeth with intact palatal/lingual bone. 6.Lesion size less than 10 mm.

Exclusion criteria

Exclusion criteria: 1.Pregnant females 2.Patient with periodontally compromised teeth. 3.Patient having insufficient motivation to report back for follow ups. 5.Lesion size greater than 10 mm. 6.Vertical root fracture

Design outcomes

Primary

Measure	Time frame
To evaluate and compare periapical healing after endodontic surgeries using Human Amniotic Membrane, hydroxyapatite graft and Laser Biostimulation using CBCT. Timepoint: Periapical healing will be evaluated at the time interval of baseline,3 months, 6 months and 12 months interval.	—

Secondary

Measure	Time frame
To find out which group among human amniotic membrane, hydroxyapatite graft And laser biostimulation will give the best healing outcome after endodontic surgeries.Timepoint: At the baseline, 3 months, 6 months And 12 months interval.	—

Countries

India

Contacts

Public ContactDr Manju kumari

ITS Dental College Hospital and Research Centre

dr.manjukumari.dntl.gn@its.edu.in09811056881

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026