Comparing effect of different flow of anaesthesia and pneumoperitoneum on intracranial pressure by measuring optic nerve sheath diameter using ultrasound machine during laparoscopic cholecystectomy surgery.

Comparison of fresh gas flow of anaesthesia and pneumoperitoneum on intracranial pressure as measured by optic nerve sheath diameter during laparoscopic cholecystectomy: a randomised clinical trial. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/05/067818

Enrollment

112

Registered

2024-05-22

Start date

Unknown

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K806- Calculus of gallbladder and bile duct with cholecystitis Health Condition 2: K807- Calculus of gallbladder and bile duct without cholecystitis Health Condition 3: K800- Calculus of gallbladder with acutecholecystitis Health Condition 4: K801- Calculus of gallbladder with othercholecystitis Health Condition 5: K802- Calculus of gallbladder without cholecystitis Health Condition 6: K808- Other cholelithiasis

Interventions

Intervention1: Comparison of fresh gas flow of anaesthesia and pneumoperitoneum on intracranial pressure as measured by optic nerve sheath diameter during laparoscopic cholecystectomy.: Comparison of

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients of either sex in the age group 18-65 years posted for elective surgery. 2. Belonging to ASA Grade I and II. 3. Patients willing to participate in the study.

Exclusion criteria

Exclusion criteria: 1. Patient unwilling to participate in the study. 2. Pregnant female. 3. Previous eye surgery. 4. Head and neck surgery. 5. Previous orbital trauma or surgical history. 6. Intracranial space covering lesions with high ICP. 7. Chronic kidney disease. 8. Cirrhosis with ascitis.

Design outcomes

Primary

Measure	Time frame
To assess the change in ONSD at 30 minutes after pneumoperitoneum among patients undergoing laparoscopic cholecystectomy with varying flow and varying intraabdominal pressure.Timepoint: 30 minutes after creation of pneumoperitoneum.	—

Secondary

Measure	Time frame
1.To assess the change in ONSD at post induction, 15 mins after pneumoperitoneum in supine position and 10 mins after desufflation. 2.To assess the change in ONSD with low flow and normal flow anaesthesia. 3.Correlation of post operative nausea vomiting and headache with change in ONSD. 4.To assess the change of hemodynamics like MAP, HR with PP, and flow of anaesthesia. 5.To assess the change of Peak airway pressure with PP and flow of anaesthesia. 6.To assess the change of ETCO2 with PP and flow of anaesthesia.Timepoint: Immediately after induction, 15 mins after pneumoperitoneum in supine position and 10 mins after desufflation.	—

Measure

Time frame

1.To assess the change in ONSD at post induction, 15 mins after pneumoperitoneum in supine position and 10 mins after desufflation. 2.To assess the change in ONSD with low flow and normal flow anaesthesia. 3.Correlation of post operative nausea vomiting and headache with change in ONSD. 4.To assess the change of hemodynamics like MAP, HR with PP, and flow of anaesthesia. 5.To assess the change of Peak airway pressure with PP and flow of anaesthesia. 6.To assess the change of ETCO2 with PP and flow of anaesthesia.Timepoint: Immediately after induction, 15 mins after pneumoperitoneum in supine position and 10 mins after desufflation.

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Countries

India

Contacts

Public ContactDr Riya Rautela

All India Institute of Medical Sciences, Gorakhpur

ankitakabi@yahoo.com9810205883

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026