A clinical study to evaluate the anesthetic efficacy of two types of local anesthetic agents during root canal treatment of symptomatic tooth

Comparison of anesthetic efficacy of 4 percent articaine with epinephrine in the ratio of 1 to 100000 as buccal infiltration and 2 percent lignocaine with epinephrine in the ratio of 1 to 80000 as inferior alveolar nerve block in patients with irreversible pulpitis A randomized clinical trial - NIL

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/05/067798

Enrollment

Registered

2024-05-22

Start date

Unknown

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K039- Disease of hard tissues of teeth,unspecified

Interventions

Intervention1: 2. 2% LIGNOCAINE WITH 1:80,000 EPINEPHRINE: Route of administration:- INFERIOR ALVEOLAR NERVE BLOCK Intervention2: 1.Articaine 2.Lignocaine: 1.4% Articaine With 1:100,000 epinephrine 2.

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients with irreversible pulpitis 2.Permanent mandibular 1st molar 3.Tooth with closed apex 4.Teeth with sound periodontal apparatus 5.Only healthy individual(ASA I or II)

Exclusion criteria

Exclusion criteria: 1.Patients allergic to amide local anesthetics 2.Non vital teeth 3.Patients taking antibiotics and/or analgesic in last 5 days 4.Retreatment cases 5.Teeth with calcified canals Pregnant and lactating women.

Design outcomes

Primary

Measure	Time frame
1.To compare the onset of anesthesia using 4% articaine with 1:100,000 epinephrine as buccal infiltration & 2% Lignocaine with 1:80,000 epinephrine as inferior alveolar nerve block. 2. To compare the duration of anesthesia using 4% articaine with 1:100,000 epinephrine as buccal infiltration & 2% Lignocaine with 1:80,000 epinephrine as inferior alveolar nerve block 3. To compare the effectiveness of anesthesia (pain assessment) using Heft Parker scale using 4% articaine with 1:100,000 epinephrine & 2% Lignocaine with 1:80,000 as inferior alveolar nerve block Timepoint: 1.Onset of anesthesia:-Time lapse between the end of the anesthesia given and onset of symptoms of subjective anesthesia 2.Duration of anesthesia:It will be calculated by recording the time of onset of anesthesia and patient reporting the loss of numbness by thorough conversation with patient over telephone 1hr ,2hr,3 hr,4 hr immediately after obturation 3.Pain asessment :Pre-operative,During the operative procedure and 6 & 12 hr after completion of the endodontic procedure	—

Measure

Time frame

1.To compare the onset of anesthesia using 4% articaine with 1:100,000 epinephrine as buccal infiltration & 2% Lignocaine with 1:80,000 epinephrine as inferior alveolar nerve block. 2. To compare the duration of anesthesia using 4% articaine with 1:100,000 epinephrine as buccal infiltration & 2% Lignocaine with 1:80,000 epinephrine as inferior alveolar nerve block 3. To compare the effectiveness of anesthesia (pain assessment) using Heft Parker scale using 4% articaine with 1:100,000 epinephrine & 2% Lignocaine with 1:80,000 as inferior alveolar nerve block Timepoint: 1.Onset of anesthesia:-Time lapse between the end of the anesthesia given and onset of symptoms of subjective anesthesia 2.Duration of anesthesia:It will be calculated by recording the time of onset of anesthesia and patient reporting the loss of numbness by thorough conversation with patient over telephone 1hr ,2hr,3 hr,4 hr immediately after obturation 3.Pain asessment :Pre-operative,During the operative procedure and 6 & 12 hr after completion of the endodontic procedure

—

Secondary

Measure	Time frame
Retrospective analysis of CBCT Scan to determine cause-effect relationship of the clinical outcome[Bone width,position of the apical foramen] Timepoint: 7 days after completion of the endodontic procedure	—

Countries

India

Contacts

Public ContactABHIJIT GHOSH

Guru Nanak Institute of Dental Sciences and Research

head_cons.gnidsr@jisgroup.org9831029606

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026