Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Group R: Will receive Sugammadex 2 mg/kg.
Sugammadex is a modified gamma-cyclodextrin which forms very tight water soluble complexes at a 1:1 ratio with steroidal neuromuscular blocking
Sponsors
Department of Anaesthesiology and Critical Care AIIMS Bhubaneswar
Eligibility
Inclusion criteria
Inclusion criteria: American Society of Anaesthesiology Physical Status 1-3 Urology surgery Requiring general anesthesia
Exclusion criteria
Exclusion criteria: Anticipated post op mechanical ventilation Severe renal impairment (creatinine more than 2mg/dl) History Of Uncontrolled thyroid disorder, MI History of anaphylaxis/severe reaction to any administered drug Consent refusal Limitation to using BIS (History of central brain injury, pacemaker, Parkinson’s)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the effect of sugammadex versus neostigmine on change of BIS value at end of surgery (time point t0 - just after skin closure) and at TOF count 4 with TOF ratio more than 0.7 (time point t1 - Primary end point)Timepoint: At time of surgery- t0 - just after skin closure t1 - TOF count 4 with TOF ratio more than 0.7 | — |
Secondary
| Measure | Time frame |
|---|---|
| Sedation score using Modified Observer Assessment of Alertness & Sedation (MOAAS) scale at timepoint t1. Clinical signs of awakening at TOF 4. (eg, sucking, grimacing, moving & coughing on the tracheal tube) Time to eye response. Emergence delirium assessed by CAM scale at 1 hour & 24 hour post extubation. Airway related complications within 30 mins post extubation.Timepoint: On day of surgery - t0 - just after skin closure t1 - TOF count 4 with TOF ratio more than 0.7 30 minutes post extubation 1 hour post extubation. 1 day after surgery - 24 hour post extubation. | — |
Countries
India
Contacts
Public ContactNitasha Misra
AIIMS Bhubaneswar
Outcome results
None listed