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Comparative evaluation of Natural vs Synthetic MMP inhibitors in patients with pulpal necrosis and apical periodontitis

Comparative evaluation of Natural vs Synthetic MMP inhibitors on MMP-2 and MMP-9 in patients with pulpal necrosis and apical periodontitis – A Randomized controlled trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/05/067682
Enrollment
34
Registered
2024-05-20
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K041- Necrosis of pulp

Interventions

Intervention1: Calcium Hydroxide with 2% Chlorhexidine: Calcium Hydroxide with 2% Chlorhexidine (1gm/ml) placed as Intracanal medicament for 7 days Intervention2: Epigallocatechin Gallate: Epigallocat

Sponsors

Palak Jain
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Mandibular premolar and canine teeth diagnosed with pulp necrosis and apical periodontitis 2 Teeth with mature apices 3 Patients with age between 18 - 60 years

Exclusion criteria

Exclusion criteria: 1 Teeth with calcified canals and aberrant root canal morphology. 2 Pregnant or lactating patients 3 Patients with history of allergy to any of the components of local anaesthesia 4 Teeth with previous RCT 5 Severely damaged or mutilated teeth 6 Patient with systemic disease 7 Patient with periodontal disease

Design outcomes

Primary

MeasureTime frame
Measure the level of MMP-2 and MMP-9 in Calcium hydroxide with 2% Chlorhexidine and Epigallocatechin gallate groups in patients with pulpal necrosis and apical periodontitis.Timepoint: Before placement of Intracanal medicament and after 7 days of placement of Intracanal medicament.—

Secondary

MeasureTime frame
To compare levels of MMP-2 & MMP-9 in patients with pulpal necrosis & apical periodontitis treated using Calcium Hydroxide with 2% Chlorhexidine & in patients with pulpal necrosis & apical periodontitis treated using epigallocatechin gallate using sandwich ELISATimepoint: Before placement of intracanal medicament & 7 days after placement of intracanal medicament—

Countries

India

Contacts

Public ContactPalak Jain

Manav Rachna Dental College

alpagupta2008@gmail.com9050312010

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026