Comparing Pain Relief Methods for Tooth Nerve Treatment: Standard Nerve Block vs. Nerve Block with Extra Gum Injection vs. Nerve Block with Laser Therapy, Using 4% Articaine, in Patients with Severe Toothache in Lower Molars: A Randomized Clinical Study

â??Comparative evaluation of anesthetic efficacy of conventional Inferior alveolar nerve block (IANB) versus IANB with supplemental intraligamentary injection and IANB with low level laser therapy (LLLT) using 4% Articaine as an anesthetic agent in patients with Symptomatic irreversible pulpitis in mandibular molars: A Randomized clinical study. ? - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/05/067668

Enrollment

225

Registered

2024-05-20

Start date

Unknown

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: IANB with supplemental intraligamentary injection: firstly IANB using 4% Articaine will be induced using intraoral route then supplemental intraligamentary injection will be given using

Eligibility

Inclusion criteria

Inclusion criteria: (1)Systemically healthy patients (Category: American Society of Anaesthesiologists class 11. Systemically healthy patients (Category: American Society of Anaesthesiologists class 1 (2)Patients who will diagnose with symptomatic irreversible pulpitis with or without apical periodontitis giving prolonged response to cold test and positive response to electric pulp test in mandibular molars (3)Patient who will actively experience moderate to severe pain pre operatively on VAS scale above 4 (on 0-10 point scale) (4)only those patients ready to sign the consent form

Exclusion criteria

Exclusion criteria: (1)Patients allergic to local anesthetics or known allergy to articaine (2)Pregnant and lactating patients (3)Patients taking any analgesics, sedatives, and antianxiety drugs on regular basis or before 24 hrs. of treatment (4)Patient having necrosed tooth with sinus tracts/local gum swelling around the affected tooth (5)Patients with severe periodontitis and poor oral hygiene

Design outcomes

Primary

Measure	Time frame
Help the clinician to decide which method of IANB nerve block ( Only IANB, IANB with intraligamentary, IANB with LLLT) will provide better anesthetic efficacy in cases of symptomatic irreversible pulpitis in lower permanent molarsTimepoint: 30 min	—

Secondary

Measure	Time frame
Help to know about the duration of onset of anesthesia using different supplemental techniquesTimepoint: 0-5 minutes, 6-10 minutes, 11-15 minutes	—

Countries

India

Contacts

Public ContactDr Nimisha Shah

K M Shah dental college

nshah7873@gmail.com9998994299

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Sep 19, 2026