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Effect on Interleukin-6 levels in saliva of the diabetic patients having periapical lesion

Evaluation of Salivary Interleukin-6 levels in Diabetic patients with periapical lesion-An In Vivo Study - NIL

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/05/067643
Enrollment
60
Registered
2024-05-20
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K044- Acute apical periodontitis of pulpal origin Health Condition 2: E119- Type 2 diabetes mellitus without complications

Interventions

Intervention1: Type 2 Diabetes mellitus with periapical lesion: This group will evaluate the salivary interleukin- 6 levels through ELISA in 15 patients with type 2 diabetes mellitus (patients who are

Sponsors

ITS Dental College Hospital And Research Centre
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients of either gender and age between 20-65 years 2. Patients with type 2 diabetes mellitus with RBS levels not more than 160 mg/dl 3. Patient with symptomatic/ asymptomatic irreversible pulpitis 4. Patients having healthy periodontal status 5. Patients consenting to participate in the study. 6. Patients with caries will be restored prior to the study.

Exclusion criteria

Exclusion criteria: 1. Patients having other systemic diseases such as hypertension, cancer, Obesity, heart diseases, Alzheimerââ?¬•s disease, pregnant women 2. Any use of medicaments such as anti-inflammatory or antibiotics in past 3 months. 3. Periapical lesion more than 4mm 4.Teeth with periodontal infections 5. Patients having habits like smoking, drinking alcohol etc

Design outcomes

Primary

MeasureTime frame
1. To evaluate and compare the levels of IL-6 before and after the root canal treatment in healthy patients 2. To evaluate and compare the levels of IL-6 before and after the root canal treatment in diabetic patients Timepoint: Baseline(on the day of onset of trial) and after 1 week(post operative)

Secondary

MeasureTime frame
To find the effect on IL-6 due to endodontic lesionsTimepoint: Baseline(on the day of onset of trial) & after 1 week(post operative)

Countries

India

Contacts

Public ContactDr Rashi Bansal

ITS Dental College Hospital And Research Centre, Greater Noida

dr.manjukumari.dntl.gn@its.edu.in9811056881

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 27, 2026