Skip to content

To see the effect of injecting a medicine around the tube used for administering anaesthesia on cough when awakening from general anesthesia after surgery,

To compare the effect of subglottic instillation of Lignocaine with intravenous Lignocaine on improving tube tolerance and maintaining hemodynamic stability during extubation- A randomized controlled double-blind study. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/05/067614
Enrollment
108
Registered
2024-05-20
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J32- Chronic sinusitis Health Condition 2: J342- Deviated nasal septum Health Condition 3: J330- Polyp of nasal cavity

Interventions

Intervention1: Intra tracheal lignocaine: 3 milliliters of lignocaine will be instilled through subglottic suction port of endotracheal tube and 3ml of normal saline will be given intravenously over o

Sponsors

NIL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anesthesiologists physical status I and II scheduled for elective nasal surgeries under general anesthesia with endotracheal tube

Exclusion criteria

Exclusion criteria: patients who are allergic to study drug (lignocaine) patients with anticipated difficult airway or at risk of aspiration will be excluded from our study Patients with retching and vomiting during emergence patients will be excluded if extubation is done less than one hour after intubation

Design outcomes

Primary

MeasureTime frame
cough score assessmentTimepoint: at 3 min, 6 min, 9 min following extubation and at 5 minutes and 10 minutes after extubation.

Secondary

MeasureTime frame
Hemodynamic parameters - heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure and SpO2 will be measured and recorded. Any complications following extubation will also be noted All study patients will be assessed for the presence of sensation of swallowing at 30 min and 60 min post-extubation All study patients will be assessed for sore throat, hoarseness of voice, odynophagia and post-operative nausea and vomiting in the immediate post-operative period and followed up till symptoms settled Timepoint: At baseline, 1 min following induction, following intubation, at the end of surgery prior to administration of the study drugs, and at 3-minute intervals following it till extubation, immediately following extubation, 5 minutes and 10 min following extubation.

Countries

India

Contacts

Public ContactDr Sripriya R

All Institute of Medical Sciences, Mangalagiri

docsripriya@gmail.com9365815939

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026