Comparison study of Green tea extract gel and Curcumin nanoparticle gel in gum disease patients along with cleaning

Comparative evaluation of clinical efficacy and total antioxidant capacity of curcumin nanoparticle gel and green tea extract gel as an adjunct to scaling & root planing and scaling and root planing alone in treatment of stage 2 periodontitis patients A split mouth study - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/05/067603

Enrollment

Registered

2024-05-17

Start date

Unknown

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Curcumin nanoparticle gel: Curcumin nanoparticle gel will be applied directly into the pocket until it overflows from the pocket at baseline following scaling and root planing Intervent

Eligibility

Inclusion criteria

Inclusion criteria: Subjects who are diagnosed with clinical stage 2 periodontitis, with probing depth greater than or equal to 5mm in at least 3 quadrants, and willing for treatment. Patients with age range of 25-55 years are included in the study and comprises of both sexes. Minimum of 15 teeth should be remaining

Exclusion criteria

Exclusion criteria: Systemically compromised patients. Use of antibiotics in the past 6 months Steroid or inflammatory drugs for 7 days in 3 months Known allergy to the above-mentioned drugs/substance Smokers and alcoholic Pregnant and lactating women Periodontal therapy within 6 months

Design outcomes

Primary

Measure	Time frame
To evaluate efficacy of curcumin nanoparticle gel and green tea extract as an adjunct to scaling and root planing on clinical parameters and total antioxidant capacity in GCF of patient with Stage 2 periodontitis.Timepoint: All clinical parameters will be measured and GCF sample collection will be done at baseline, 1 month and 3 months after the therapy. Gel application will be done at baseline	—

Secondary

Measure	Time frame
To compare the efficacy of curcumin nanoparticle gel and green tea extract gel as an adjunct to scaling root planing and scaling and root planing alone on clinical parameters and antioxidant capacity in GCF of patient with Stage 2 periodontitis.Timepoint: All clinical parameters will be measured and GCF sample collection will be done at baseline, 1 month and 3 months after the therapy. Gel application will be done at baseline	—

Measure

Time frame

To compare the efficacy of curcumin nanoparticle gel and green tea extract gel as an adjunct to scaling root planing and scaling and root planing alone on clinical parameters and antioxidant capacity in GCF of patient with Stage 2 periodontitis.Timepoint: All clinical parameters will be measured and GCF sample collection will be done at baseline, 1 month and 3 months after the therapy. Gel application will be done at baseline

—

Countries

India

Contacts

Public ContactDr Radhika B

Coorg Institute of Dental Sciences

kuriakosedikson@gmail.com7736977565

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026