Health Condition 1: L120- Bullous pemphigoid
Conditions
Interventions
Intervention1: Nil: Nil
Control Intervention1: Nil: Nil
Sponsors
Kasturba Medical College Manipal
Saurodeep Basu
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients with a clinical diagnosis consistent with bullous pemphigoid as per the standard diagnostic criteria. 2. Direct immunofluorescence (DIF) microscopy showing linear deposits of IgG and/or Complement C3 along the basement membrane zone. 3. Indirect immunofluorescence (IIF) of salt-split skin biopsy showing deposition of IgG along the basement membrane zone, if done.
Exclusion criteria
Exclusion criteria: 1. Severe bleeding and coagulation disorders. 2. Failure to obtain written informed consent for skin biopsy. 3. Severely immunosuppressed conditions, including acquired immunodeficiency syndrome (AIDS).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Demonstration of anti-IgE antibodies in basement membrane zone by direct immunofluorescence (DIF) microscopyTimepoint: During hospital stay or on OPD basis | — |
Secondary
| Measure | Time frame |
|---|---|
| • Correlation of anti-BMZ IgE antibodies in skin biopsy with patient characteristics (age, gender, clinical manifestations and duration of the disease) • Bullous pemphigoid disease area index (BPDAI) score • Association between anti-BMZ IgE antibodies in skin biopsy with eosinophil and basophil count in the peripheral blood, and serum IgE and IgG (against BP180 and BP230), if doneTimepoint: During hospital stay or on OPD basis | — |
Countries
India
Contacts
Public ContactSaurodeep Basu
Kasturba Medical College Manipal
Outcome results
None listed